ArticleImmunity & ageing : I & A2019
Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.
Article in Immunity & ageing : I & A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Mucosal Immune Responses in People Living with HIV May Confer Protection from SARS-CoV-2 Infections After COVID-19 Vaccination.Vaccines · 2026Article
- CD28 co-stimulation: novel insights and applications in cancer immunotherapy.Nature reviews. Immunology · 2024Review
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- Accumulation of CD28Biomolecules · 2021Review
- Uremia-Associated Immunological Aging and Severity of COVID-19 Infection.Frontiers in medicine · 2021Review
- Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.Antioxidants (Basel, Switzerland) · 2020Article
- Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders.International journal of molecular sciences · 2020Review
- Review
- CD28 and CD57 define four populations with distinct phenotypic properties within human CD8European journal of immunology · 2020Article
- Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis.Frontiers in endocrinology · 2020Review
- The immune response to influenza in older humans: beyond immune senescence.Immunity & ageing : I & A · 2020Review
- The impact of body mass index on adaptive immune cells in the human bone marrow.Immunity & ageing : I & A · 2020Article
- The impact of oxidative stress, inflammation, and senescence on the maintenance of immunological memory in the bone marrow in old age.Bioscience reports · 2019Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAntigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations in the BM changes with age, leading to an accumulation of highly differentiated T cells and a loss of naïve T cells. While innate immune cells are also affected by age, little is known about interactions between different adaptive immune cell populations maintained in the BM. In this study, the phenotype and function of innate and adaptive immune cells isolated from human BM and peripheral blood (PB) was analysed in detail using flow cytometry, to determine if the accumulation of highly differentiated T and B cells, supported by the BM niches, limits the maintenance of other immune cells, or affects their functions such as providing protective antibody concentrations.
resultsTotal T cells increase in the BM with age, as do highly differentiated CD8
conclusionOur data suggest that the accumulation and maintenance of highly differentiated, senescent, and exhausted T cells in the BM, particularly in old age, may interfere with the survival of other cell populations resident in the BM such as monocytes and B cells, leading to reduced peripheral diphtheria antibody concentrations as a result. These findings further highlight the importance of the BM in the long-term maintenance of immunological memory.
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