ArticleScientific reports2019
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- A hierarchical clinical fusion transformer model for personalized opioid treatment: Development and validation in diabetic surgical patients.medRxiv : the preprint server for health sciences · 2026Article
- Pharmacogenomics and Pharmacometabolomics in Precision Tramadol Prescribing for Enhanced Pain Management: Evidence from QBB and EMR Data.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Diazoxide as a bridging therapy in methadone-induced hypoglycemia- a case report and review of the literature.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Article
- Methadone-Induced Hypoglycemia in a Hospitalized Patient.Hospital pharmacy · 2024Article
- Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment.Reviews in endocrine & metabolic disorders · 2023Review
- Methadone-induced hypoglycemia: A case report.Journal of diabetes investigation · 2023Article
- Insulinoma mimic: methadone-induced hypoglycaemia.BMJ case reports · 2022Article
- Comparison of Online Patient Reviews and National Pharmacovigilance Data for Tramadol-Related Adverse Events: Comparative Observational Study.JMIR public health and surveillance · 2022Observational
- Article
- The Effect of Different Opioids on Acid-Base Balance and Blood Gas Analysis in Hospitalized Dogs.Frontiers in veterinary science · 2022Article
- Myocarditis occurrence with cancer immunotherapy across indications in clinical trial and post-marketing data.Scientific reports · 2021Article
- Orthogeriatrics: a vital requirement for improving fragility fracture patient care internationally with particular reference to Turkey.Archives of osteoporosis · 2021Review
- Concomitant drugs associated with increased mortality for MDMA users reported in a drug safety surveillance database.Scientific reports · 2021Article
- Changes on proteomic and metabolomic profile in serum of mice induced by chronic exposure to tramadol.Scientific reports · 2021Article
- Postmarketing safety surveillance data reveals antidepressant effects of botulinum toxin across various indications and injection sites.Scientific reports · 2020Article
- An unconscious man with profound drug-induced hypoglycaemia.Biochemia medica · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines. Its pain-relieving mechanism of action is attributed to mild μ-opioid receptor agonism, serotonin and norepinephrine mediated nociception modulation, and N-methyl-D-aspartate receptor, NMDAR, antagonism. However, recent case reports and case-control studies have shown an association between tramadol use and hypoglycemia. The growing concern over increasing tramadol use and unexpected side effects warranted a further comparative and quantitative analysis of tramadol adverse reactions. In this study we analyzed over twelve million reports from United States Food and Drug Administration Adverse Event Reporting System and provided evidence of increased propensity for hypoglycemia in patients taking tramadol when compared to patients taking other opioids, serotonin-norepinephrine reuptake inhibitors, and drugs affecting NMDAR activity. Additionally, we identified that only methadone from the opioid cohort behaves similarly to tramadol and has an association with hypoglycemia.
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