Evidence map›Paper›PMID 31462583›Full record

ArticleNeurology2019

Noncommunicable disease among adults with cerebral palsy: A matched cohort study.

Jennifer M Ryan, Mark D Peterson, Anthony Matthews, Nicola Ryan, Kimberley J Smith, Neil E O'Connell, Silvia Liverani, Nana Anokye, Christina Victor, Elizabeth Allen

Abstract read
In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. Diaphragm muscle function in a mouse model of early-onset spasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer M RyanFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK. jenniferryan@rcsi.com.
Mark D PetersonFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Anthony MatthewsFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Nicola RyanFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK. jenniferryan@rcsi.com.
Kimberley J SmithFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Neil E O'ConnellFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Silvia LiveraniFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Nana AnokyeFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Christina VictorFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.
Elizabeth AllenFrom the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal College of Surgeons in Ireland, Dublin; Institute of Environment, Health and Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department of Physical Medicine and Rehabilitation (M.D.P.), University of Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK; Department of Interventional Cardiology (N.R.), Hospital Clínico San Carlos, Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health and Medical Sciences, University of Surrey, Guildford; and School of Mathematical Sciences (S.L.), Queen Mary University of London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the incidence of noncommunicable diseases between adults with and without cerebral palsy (CP).

methodsA cohort study was conducted using primary care data from the Clinical Practice Research Datalink. Cox models, stratified by matched set and adjusted for potential confounders, were fitted to compare the risk of any noncommunicable disease, cancer, cardiovascular disease, type 2 diabetes mellitus, and respiratory disease between adults with and without CP.

resultsThe analysis included 1,705 adults with CP and 5,115 age-, sex-, and general practice-matched adults without CP. There was evidence from adjusted analyses that adults with CP had 75% increased risk of developing any noncommunicable disease compared to adults without CP (hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.58-1.94). Specifically, they had increased risk of cardiovascular disease (HR 1.76, 95% CI 1.48-2.11) and respiratory disease (HR 2.61, 95% CI 2.14-3.19). There was no evidence of increased risk of cancer or type 2 diabetes mellitus.

conclusionsAdults with CP had increased risk of noncommunicable disease, specifically cardiovascular and respiratory disease. These findings highlight the need for clinical vigilance regarding identification of noncommunicable disease in people with CP and further research into the etiology and management of noncommunicable disease in this population.

Indexed as

AdultCardiovascular DiseasesCerebral PalsyCohort StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansMaleMiddle AgedNoncommunicable DiseasesRespiration DisordersRisk Factors

Identifiers

PMID31462583
PMCPMC6814410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.