Evidence map›Paper›PMID 31462567›Full record

ArticleJournal of virology2019

Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model.

Szu-Yao Wu, Ya-Shu Chang, Tien-Hua Chu, Chiaho Shih

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Viruses · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Szu-Yao WuProgram in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.
Ya-Shu ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tien-Hua ChuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chiaho ShihInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan cshih@ibms.sinica.edu.tw.
Institute of Biomedical Sciences, Academia Sinica · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations in natural infection. Wild-type HBV is known to secrete predominantly virions containing mature DNA genome. However, a frequent naturally occurring HBc variant, I97L, changing from an isoleucine to a leucine at amino acid 97, exhibited an immature secretion phenotype in culture, which preferentially secretes virions containing immature genomes. In contrast, mutant P130T, changing from a proline to a threonine at amino acid 130, exhibited a hypermaturation phenotype by accumulating an excessive amount of intracellular fully mature DNA genome. Using a hydrodynamic delivery mouse model, we studied the

Indexed as

AnimalsDisease Models, AnimalDNA, ViralGenome, ViralHepatitis BHepatitis B Core AntigensHepatitis B virusIsoleucineLeucineMaleMiceMice, Inbred BALB CMutationPhenotypeViral Core ProteinsVirionDNA, ViralHepatitis B Core AntigensIsoleucineLeucineViral Core Proteinsgenome maturationHBVHBV core antigenHBV core proteinhepatitis B virushydrodynamic mouse modelimmature virion secretionmouse modelnaturally occurring mutationnaturally occurring variantsvirion secretion

Identifiers

PMID31462567
PMCPMC6819939
OpenAlexW2971163945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.