Evidence map›Paper›PMID 31462558›Full record

ArticleJournal of virology2019

Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.

Bryan A Johnson, Adam Hage, Birte Kalveram, Megan Mears, Jessica A Plante, Sergio E Rodriguez, Zhixia Ding, Xuemei Luo, Dennis Bente, Shelton S Bradrick and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. The Surfactin-Like Lipopeptides FromFrontiers in bioengineering and biotechnology · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Membrane-Targeting Antivirals.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Bryan A JohnsonDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Adam HageDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Birte KalveramDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Megan MearsDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Jessica A PlanteWorld Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Sergio E RodriguezDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.ORCID 0000-0003-4149-7458
Zhixia DingDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Xuemei LuoDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Dennis BenteDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Shelton S BradrickDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Alexander N FreibergDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Vsevolod PopovDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Ricardo RajsbaumDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Shannan RossiDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
William K RussellDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Vineet D MenacheryDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA Vimenach@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCWEENEY, SHANNON K. · 2012 to 2021
$36.6M
World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
Regulation of Ebola virus replication by the host ubiquitin systemR01AI134907 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GIRALDO, MARIA ISABEL · 2018 to 2022
$3.1M
EMERGING AND TROPICAL INFECTIOUS DISEASEST32AI007526 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SOONG, LYNN · 1997 to 2025
$3.1M
Systems Based Analysis of Host Factors that Contribute to Aging PathogenesisR00AG049092 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENACHERY, VINEET D · 2017 to 2019
$736k
The role of the host ubiquitin system in Zika virus replicationR21AI132479 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAJSBAUM, RICARDO · 2017 to 2018
$426k
Unanchored Polyubiquitin Chains and Innate Immunity to Influenza VirusR21AI126012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAJSBAUM, RICARDO · 2017 to 2018
$426k
NIAID NIH HHS R01 AI134907NIAID NIH HHS R21 AI126012NIAID NIH HHS R21 AI132479NIAID NIH HHS R24 AI120942NIAID NIH HHS T32 AI007526NIAID NIH HHS U19 AI100625NIA NIH HHS R00 AG049092
6 · The paper itself

Abstract

Enteric viruses exploit bacterial components, including lipopolysaccharides (LPS) and peptidoglycan (PG), to facilitate infection in humans. Because of their origin in the bat enteric system, we wondered if severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome CoV (MERS-CoV) also use bacterial components to modulate infectivity. To test this question, we incubated CoVs with LPS and PG and evaluated infectivity, finding no change following LPS treatment. However, PG from

Indexed as

AnimalsCell LineChlorocebus aethiopsCoronavirus InfectionsFlaviviridaeLipopeptidesMiddle East Respiratory Syndrome CoronavirusPeptides, CyclicPeptidoglycanRNA VirusesSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusVero CellsVirus DiseasesLipopeptidesPeptides, CyclicPeptidoglycansurfactin peptidecoronaviruscyclic lipopeptideMERS-CoVmicrobiomeSARS-CoVsurfactin

Identifiers

PMID31462558
PMCPMC6819921
OpenAlexW2969721961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.