Evidence map›Paper›PMID 31462388›Full record

ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2019

Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood.

Marsida Kallupi, Giordano de Guglielmo, Estefania Larrosa, Olivier George

Abstract read
In one paragraph

Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  9. Article
  10. Article
  11. The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  16. Unique, long-term effects of nicotine on adolescent brain.Pharmacology, biochemistry, and behavior · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marsida KallupiDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, United States. Electronic address: mkallupi@scripps.edu.
Giordano de GuglielmoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, United States.
Estefania LarrosaDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, United States.
Olivier GeorgeDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, United States. Electronic address: olgeorge@ucsd.edu.

Funding

Alcohol Vapor Self-Administration in RatsR01AA022977 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Olivier George · 2014 to 2026
$5.1M
Effect of Exposure to Nicotine Vapor on the Vulnerability to Nicotine DependenceR21DA036691 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI GEORGE, OLIVIER · 2014 to 2016
$530k
NIAAA NIH HHS R01 AA022977NIDA NIH HHS R21 DA036691
6 · The paper itself

Abstract

Electronic cigarette use is particularly prevalent in adolescents, but the effects of secondhand exposure to nicotine vapor in adolescents on the propensity to develop nicotine dependence and increase nicotine self-administration in adulthood are poorly known. The present study explored the effects of nicotine vapor exposure on withdrawal-like states (hyperalgesia, spontaneous withdrawal signs, and locomotor activity) in adolescent rats and the vulnerability to acquire intravenous nicotine self-administration in adulthood. Adolescent (postnatal day 38) rats were exposed to intermittent nicotine vapor (14 h/day) for 7 consecutive days in a range of doses (0, 0.4, and 7 mg/m

Indexed as

Administration, InhalationAdministration, IntravenousAge FactorsAnimalsConditioning, OperantDrug Administration ScheduleMaleNicotineRatsSelf AdministrationSubstance Withdrawal SyndromeNicotineAbstinenceDependencePainSecondhand exposureTobacco

Identifiers

PMID31462388
PMCPMC7899081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.