SynthesisPsychological medicine2020
Use of illicit substances and violent behaviour in psychotic disorders: two nationwide case-control studies and meta-analyses.
Synthesis in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Suicidal risk in patients with aggression in schizophrenia: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Drug Use Disorders and Violence: Associations With Individual Drug Categories.Epidemiologic reviews · 2020Pooled it
- Assessing Cannabis Use in People with Psychosis.Cannabis and cannabinoid research · 2024Review
- Cognitive and clinical characteristics of offenders and non-offenders diagnosed with schizophrenia spectrum disorders: results of the Recoviwel observational study.European archives of psychiatry and clinical neuroscience · 2023Observational
- Characteristics and associated factors of violence in male patients with schizophrenia in China.Frontiers in psychiatry · 2023Article
- Aggression, Alexithymia and Sense of Coherence in a Sample of Schizophrenic Outpatients.Healthcare (Basel, Switzerland) · 2022Article
- Validation and recalibration of OxMIV in predicting violent behaviour in patients with schizophrenia spectrum disorders.Scientific reports · 2022Article
- The Link Between Cannabis Use and Violent Behavior in the Early Phase of Psychosis: The Potential Role of Impulsivity.Frontiers in psychiatry · 2022Article
- The Prediction and Influential Factors of Violence in Male Schizophrenia Patients With Machine Learning Algorithms.Frontiers in psychiatry · 2022Article
- Violence, neurocognitive function and clinical correlates in patients with schizophrenia.Frontiers in psychiatry · 2022Article
- Patterns and Predictors of Reincarceration among Prisoners with Serious Mental Illness: A Cohort Study: Modèles et prédicteurs de réincarcération chez les prisonniers souffrant de maladie mentale grave : Une étude de cohorte.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Substance Use Disorders as a Critical Element for Decision-Making in Forensic Assertive Community Treatment: A Systematic Review.Frontiers in psychiatry · 2021Review
- Aggression Amongst Outpatients With Schizophrenia and Related Psychoses in a Tertiary Mental Health Institution.Frontiers in psychiatry · 2021Article
- Spectral trends in GC-EI-MS data obtained from the SWGDRUG mass spectral library and literature: A resource for the identification of unknown compounds.Forensic chemistry (Amsterdam, Netherlands) · 2020Article
- Early onset of cannabis use and violent behavior in psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- The prevalence of mental disorders and patterns of comorbidity within a large sample of mentally ill prisoners: A network analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Violent outcomes in first-episode psychosis: A clinical cohort study.Early intervention in psychiatry · 2020Article
- Ethics and ego dissolution: the case of psilocybin.Journal of medical ethics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundSubstance use disorder explains much of the excess risk of violent behaviour in psychotic disorders. However, it is unclear to what extent the pharmacological properties and subthreshold use of illicit substances are associated with violence.
methodsIndividuals with psychotic disorders were recruited for two nationwide projects: GROUP (N = 871) in the Netherlands and NEDEN (N = 921) in the United Kingdom. Substance use and violent behaviour were assessed with standardized instruments and multiple sources of information. First, we used logistic regression models to estimate the associations of daily and nondaily use with violence for cannabis, stimulants, depressants and hallucinogens in the GROUP and NEDEN samples separately. Adjustments were made for age, sex and educational level. We then combined the results in random-effects meta-analyses.
resultsDaily use, compared with nondaily or no use, and nondaily use, compared with no use, increased the pooled odds of violence in people with psychotic disorders for all substance categories. The increases were significant for daily use of cannabis [pooled odds ratio (pOR) 1.6, 95% confidence interval (CI) 1.2-2.0), stimulants (pOR 2.8, 95% CI 1.7-4.5) and depressants (pOR 2.2, 95% CI 1.1-4.5), and nondaily use of stimulants (pOR 1.6, 95% CI 1.2-2.0) and hallucinogens (pOR 1.5, 95% CI 1.1-2.1). Daily use of hallucinogens, which could only be analysed in the NEDEN sample, significantly increased the risk of violence (adjusted odds ratio 3.3, 95% CI 1.2-9.3).
conclusionsStrategies to prevent violent behaviour in psychotic disorders should target any substance use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.