SynthesisPsychological medicine2021
Predictors of treatment resistant schizophrenia: a systematic review of prospective observational studies.
Synthesis in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Knowledge domain and trends in treatment-resistant schizophrenia (TRS) research based on CiteSpace bibliometrics analysis.Frontiers in pharmacology · 2024Pooled it
- Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia.Psychiatry and clinical neurosciences · 2026Article
- Clozapine prescribing in Germany: temporal trends and regional variations, 2012-2022.Schizophrenia (Heidelberg, Germany) · 2026Article
- Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia.Translational psychiatry · 2026Article
- Why Is Clozapine Uniquely Effective in Treatment-Resistant Schizophrenia? A Review and Proposal.Biological psychiatry · 2026Review
- Emerging Neurobiological and Therapeutic Insights into Schizophrenia: A Comprehensive Review.International journal of molecular sciences · 2026Review
- UntargetedTranslational psychiatry · 2026Article
- Genetics to Improve Outcomes in Schizophrenia (GENios): A within-case molecular genetic study protocol.PloS one · 2026Article
- Effect of a logotherapy-based psychoeducational program on interpersonal guilt, self-efficacy, and resilience in patients with schizophrenia: a quasi-experimental study.BMC psychiatry · 2025Article
- Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis.Translational psychiatry · 2025Article
- Latent Trajectories of Positive, Negative Symptoms and Functioning in Early Intervention Services for First-Episode Psychosis: A 2-Year Follow-Up Study.Schizophrenia bulletin · 2025Article
- First Episode Psychosis in Patients Aged 18 to 30 Admitted Involuntarily: Characteristics and Risk Factors for Functional Non-Remission.Brain sciences · 2025Article
- Cognitive functioning and functional ability in women with schizophrenia and homelessness.Schizophrenia research. Cognition · 2025Article
- Efficacy of identifying Treatment-Resistant and non-Treatment-Resistant Schizophrenia using niacin skin flushing response combined with clinical feature.Schizophrenia (Heidelberg, Germany) · 2025Article
- Research on the influencing factors of the development of metabolic syndrome in patients with schizophrenia and the intervention effect of dance movement therapy.Frontiers in psychiatry · 2025Article
- Home, school, and the hidden cost of parental mental health.Frontiers in psychology · 2025Article
- Network analysis of clinical features in patients with treatment-resistant schizophrenia.Frontiers in psychiatry · 2025Article
- Multimodal prediction of the need of clozapine in treatment resistant schizophrenia; a pilot study in first-episode psychosis.Biomarkers in neuropsychiatry · 2024Article
- Improving outcome of treatment-resistant schizophrenia: effects of cognitive remediation therapy.European archives of psychiatry and clinical neuroscience · 2024Article
- [Management of treatment resistance-Treatment-resistant schizophrenia].Der Nervenarzt · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Treatment-resistant schizophrenia, affecting approximately 20-30% of patients with schizophrenia, has a high burden both for patients and healthcare services. There is a need to identify treatment resistance earlier in the course of the illness, in order that effective treatment, such as clozapine, can be offered promptly. We conducted a systemic literature review of prospective longitudinal studies with the aim of identifying predictors of treatment-resistant schizophrenia from the first episode. From the 545 results screened, we identified 12 published studies where data at the first episode was used to predict treatment resistance. Younger age of onset was the most consistent predictor of treatment resistance. We discuss the gaps in the literature and how future prediction models can identify predictors of treatment response more robustly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.