Evidence map›Paper›PMID 31462158›Full record

ArticleAutophagy2020

The transcription factor Spt4-Spt5 complex regulates the expression of

Xin Wen, Damián Gatica, Zhangyuan Yin, Zehan Hu, Jörn Dengjel, Daniel J Klionsky

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Downregulation of autophagy by Met30-mediated Atg9 ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xin WenLife Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, MI, USA.
Damián GaticaLife Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, MI, USA.
Zhangyuan YinLife Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, MI, USA.
Zehan HuDepartment of Biology, University of Fribourg , Fribourg, Switzerland.
Jörn DengjelDepartment of Biology, University of Fribourg , Fribourg, Switzerland.
Daniel J KlionskyLife Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, MI, USA.ORCID 0000-0002-7828-8118
University of Michigan · USUniversity of Fribourg · CH

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Macroautophagy/autophagy, a highly conserved dynamic process, is one of the major degradative pathways in cells. So far, over 40 autophagy-related ( ABBREVIATIONS: AID: auxin-inducible degron; ATG: autophagy-related; ChIP: chromatin immunoprecipitation;Cvt: cytoplasm-to-vacuole targeting; DSIF: DRB sensitivity-inducible factor; NELF: negativeelongation factor; ORF: open reading frame; PA: protein A; PE: phosphatidylethanolamine;prApe1: precursor aminopeptidase I; RT-qPCR: real-time quantitative PCR; RNAP II: RNApolymerase II; TSS: transcription start site; WT: wild-type.

Indexed as

AutophagyDNA, FungalGene Expression Regulation, FungalModels, BiologicalPhosphorylationRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsTranscription, GeneticUp-RegulationDNA, FungalRNA, MessengerSaccharomyces cerevisiae ProteinsTranscription FactorsAutophagySpt4Spt5stressvacuoleyeast

Identifiers

PMID31462158
PMCPMC7469535
OpenAlexW2970226338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.