Evidence map›Paper›PMID 31462148›Full record

ArticleAutophagy2020

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.

Meysam Yazdankhah, Peng Shang, Sayan Ghosh, Imran A Bhutto, Nadezda Stepicheva, Rhonda Grebe, Stacey Hose, Joseph Weiss, Tianqi Luo, Subrata Mishra and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Article
  7. Review
  8. Role of glia in optic nerve.Progress in retinal and eye research · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Meysam YazdankhahGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Peng ShangGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Sayan GhoshGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Imran A BhuttoGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Nadezda StepichevaGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Rhonda GrebeThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.ORCID 0000-0003-1841-9777
Stacey HoseGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Joseph WeissGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Tianqi LuoThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Subrata MishraThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.
S Amer RiazuddinThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Arkasubhra GhoshGROW Research Laboratory, Narayana Nethralaya Foundation , Bengaluru, India.
James T HandaThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Gerard A LuttyThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.
J Samuel ZiglerThe Wilmer Eye Institute, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Debasish SinhaGlia Research Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Johns Hopkins University · USUniversity of Pittsburgh · USNarayana Nethralaya · IN

Funding

A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculatureR01EY019037 · NEI · JOHNS HOPKINS UNIVERSITY · PI SINHA, DEBASISH · 2008 to 2015
$4.1M
NEI NIH HHS R01 EY019037
6 · The paper itself

Abstract

Persistent fetal vasculature (PFV) is a human disease that results from failure of the fetal vasculature to regress normally. The regulatory mechanisms responsible for fetal vascular regression remain obscure, as does the underlying cause of regression failure. However, there are a few animal models that mimic the clinical manifestations of human PFV, which can be used to study different aspects of the disease. One such model is the Nuc1 rat model that arose from a spontaneous mutation in the ABBREVIATIONS: ACTB: actin, beta; CCND3: cyclin 3; CDK6: cyclin-dependent kinase 6; CHQ: chloroquine; COL4A1: collagen, type IV, alpha 1; CRYBA1: crystallin, beta A1; DAPI: 4'6-diamino-2-phenylindole; EGFR: epidermal growth factor receptor; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFAP: glial fibrillary growth factor; KDR: kinase insert domain protein receptor; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MKI67: antigen identified by monoclonal antibody Ki 67; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP: poly (ADP-ribose) polymerase family; PCNA: proliferating cell nuclear antigen; PFV: persistent fetal vasculature; PHPV: persistent hyperplastic primary vitreous; RPE: retinal pigmented epithelium; RPS6: ribosomal protein S6; RPS6KB1: ribosomal protein S6 kinase, polypeptide 1; SQSTM1/p62: sequestome 1; TUBB: tubulin, beta; VCL: vinculin; VEGFA: vascular endothelial growth factor A; WT: wild type.

Indexed as

AnimalsAstrocytesAutophagybeta-Crystallin A ChainCell MovementCell ProliferationCells, CulturedDisease Models, AnimalErbB ReceptorsEyeGefitinibLysosomesMechanistic Target of Rapamycin Complex 1Microscopy, ImmunoelectronMorpholinesPersistent Hyperplastic Primary Vitreous(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolbeta-Crystallin A ChainErbB ReceptorsGefitinibMechanistic Target of Rapamycin Complex 1MorpholinesSirolimusAstrocytesautophagyCRYBA1 (ßA3/A1-crystallin)EGFR (epidermal growth factor receptor)gefitinibhyaloid vesselslysosomesMTORC1 (mechanistic target of rapamycin complex 1)Nuc1 ratpersistent fetal vasculature (PFV) disease

Identifiers

PMID31462148
PMCPMC7469569
OpenAlexW2970930232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.