ArticleCell transplantation2019
Rat Facial Nerve Regeneration with Human Immature Dental Pulp Stem Cells.
Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration.Bioactive materials · 2025Article
- The potential role of SCF combined with DPCs in facial nerve repair.Journal of molecular histology · 2025Article
- Facial Nerve Regeneration in Immunodeficient Rats Using a Bio 3D Conduit Fabricated From Human Dental Pulp Stem Cells.Stem cells international · 2025Article
- Therapeutic Potential of Vitamin B Complex in Peripheral Nerve Injury Recovery: An Experimental Rat Model Study.Medicina (Kaunas, Lithuania) · 2024Article
- Dental Pulp-Derived Mesenchymal Stem Cells Increase Axon Numbers in Mental Nerve Repair.Journal of maxillofacial and oral surgery · 2024Article
- Role of transforming growth factor-β in peripheral nerve regeneration.Neural regeneration research · 2024Review
- Graphene/ chitosan tubes inoculated with dental pulp stem cells promotes repair of facial nerve injury.Frontiers in chemistry · 2024Article
- The Effect of Differentiation of Human Dental Pulp Stem Cells to Glial Cells on the Sensory Nerves of the Dental Pulp.International journal of dentistry · 2024Article
- Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications.World journal of stem cells · 2023Review
- Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2023Review
- Stem Cells and Tissue Engineering-Based Therapeutic Interventions: Promising Strategies to Improve Peripheral Nerve Regeneration.Cellular and molecular neurobiology · 2023Review
- Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits.ACS omega · 2022Article
- Repairing whole facial nerve defects with xenogeneic acellular nerve grafts in rhesus monkeys.Neural regeneration research · 2022Article
- Facial Nerve Repair: Bioengineering Approaches in Preclinical Models.Tissue engineering. Part B, Reviews · 2022Review
- Potential Therapeutic Strategies and Substances for Facial Nerve Regeneration Based on Preclinical Studies.International journal of molecular sciences · 2021Review
- Overexpression of Foxc1 regenerates crushed rat facial nerves by promoting Schwann cells migration via the Wnt/β-catenin signaling pathway.Journal of cellular physiology · 2020Article
- Dental Tissue-Derived Human Mesenchymal Stem Cells and Their Potential in Therapeutic Application.Stem cells international · 2020Review
- The Regenerative Potential of Facial Nerve Motoneurons following Chronic Axotomy in Rats.Neural plasticity · 2020Article
- Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Facial paralysis can result in severe implications for the patients. However, stem cell biology has become an important field in regenerative medicine since the discovery and characterization of mesenchymal stem cells. Our aim was to evaluate the regeneration after facial nerve crush injury and application of human immature dental pulp stem cells (iDPSC). For this study 70 Wistar rats underwent a unilateral facial nerve crush injury and were divided into two groups: Group I (GI): Crushed; Group II (GII): Crushed and iDPSC, and distributed into study periods of 3, 7, 14, 21, and 42 postoperative days. Facial nerve regeneration was analyzed via functional recovery of whisker movement, histomorphometric analysis, and immunoblotting assay. The results show that GII had complete functional recovery at 14 days, while GI recovered after 42 days. Also, regarding the facial nerve trunk, GII presented histological improvement, evidencing better axonal and structural organization of the myelin sheath, and exhibited statistically higher values for the outer and inner perimeters and g-ratio. Nevertheless, GI exhibited statistically higher values for the thickness of myelin sheath. In the buccal branch, no differences were observed for all parameters between groups. At 42 days, both groups GI and GII were close to the levels observed for the control group. Concerning nerve growth factor expression, GII exhibited statistically greater values (
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