ArticleJournal of clinical medicine2019
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Endothelial Exostosin-1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Hyaluronan and Syndecan-1: Linking Glycocalyx Degradation to Development and Progression of Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2026Article
- Serum Syndecan-1 is Associated With Kidney and Cardiovascular Outcomes in Idiopathic Nephrotic Syndrome.Kidney international reports · 2025Article
- Clinicopathological Study on Endothelial Injury in Severe Glomerular Microangiopathy Induced by Ramucirumab.Internal medicine (Tokyo, Japan) · 2025Article
- Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases.Trauma surgery & acute care open · 2025Article
- Association of endotheliopathy with coagulofibrinolytic reactions and disseminated intravascular coagulation after trauma: a retrospective observational study.Scientific reports · 2024Observational
- Kinetics of cardiovascular and inflammatory biomarkers in paediatric dengue shock syndrome.Oxford open immunology · 2024Article
- Investigation of the relationship between intradialytic hypotension during hemodialysis and serum syndecan-1 concentration.Scientific reports · 2023Article
- Serum syndecan-1 concentration in hemolysis, elevated liver enzymes, and low platelets syndrome: A case report.Frontiers in medicine · 2023Article
- Markers of endothelial glycocalyx dysfunction in Clarkson disease.Journal of translational medicine · 2022Article
- The endothelial glycocalyx in critical illness: A pediatric perspective.Matrix biology plus · 2022Article
- Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease.Frontiers in cardiovascular medicine · 2022Article
- A Prediction Equation to Estimate Vascular Endothelial Function in Different Body Mass Index Populations.Frontiers in cardiovascular medicine · 2022Article
- Syndecan-1 as a severity biomarker for patients with trauma.Frontiers in medicine · 2022Article
- Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19.Thrombosis journal · 2021Article
- Serum syndecan-1 reflects organ dysfunction in critically ill patients.Scientific reports · 2021Article
- Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury.Thrombosis journal · 2021Article
- Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival.PloS one · 2021Article
- Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx Injury During Hemodialysis.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 3 institutions in 1 country.
Funding
Abstract
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.