Evidence map›Paper›PMID 31461977›Full record

ArticleInternational journal of molecular sciences2019

Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway.

Ye-Bo Zhou, Hong Zhou, Li Li, Ying Kang, Xu Cao, Zhi-Yuan Wu, Lei Ding, Gautam Sethi, Jin-Song Bian

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Hypotaurine Reduces Glucose-Mediated Vascular Calcification.Acta physiologica (Oxford, England) · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Diabetic Nephropathy and Gaseous Modulators.Antioxidants (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. The Role of Hydrogen Sulfide in Plaque Stability.Antioxidants (Basel, Switzerland) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ye-Bo ZhouDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Hong ZhouDepartment of Physiology, Nanjing Medical University, Nanjing 211166, China.
Li LiDepartment of Pathophysiology, Xuzhou Medical University, Xuzhou 221004, China.
Ying KangDepartment of Physiology, Nanjing Medical University, Nanjing 211166, China.
Xu CaoDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Zhi-Yuan WuDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Lei DingDepartment of Pathophysiology, Xuzhou Medical University, Xuzhou 221004, China.
Gautam SethiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Jin-Song BianDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. phcbjs@nus.edu.sg.
National University of Singapore · SGNanjing Medical University · CNXuzhou Medical College · CN

Funding

Ministry of Education of Singapore Tier 2 Research grant MOE2017-T2-2-029NMRC CIRG1432/2015
6 · The paper itself

Abstract

Vascular calcification can be enhanced by hyperglycemia. Elastin loss in tunica media promotes the osteogenic transformation of smooth muscle cells (SMCs) and involves arterial medial calcification (AMC) that is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes. Here, we tested whether hydrogen sulfide (H

Indexed as

CalciumCathepsinsCells, CulturedElastinGlucoseHumansHydrogen SulfideMuscle, Smooth, VascularMyocytes, Smooth MusclePhosphorusSignal TransductionSTAT3 Transcription FactorSulfidesVascular CalcificationCalciumcathepsin SCathepsinsElastinGlucoseHydrogen SulfidePhosphorussodium bisulfideSTAT3 protein, humanSTAT3 Transcription FactorSulfidescalcificationcathepsin Selastinhydrogen sulfidesmooth muscle cellsStat3

Identifiers

PMID31461977
PMCPMC6747320
OpenAlexW2971347813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.