ArticleViruses2019
Evolution and Genetic Diversity of Porcine Circovirus 3 in China.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Beyond labels: current sequencing data do not support standardized porcine circovirus 3 (PCV3) genotypes.BMC veterinary research · 2026Article
- Article
- Molecular Surveillance and Evolutionary Dynamics of Porcine Circovirus Types 2 and 3 in China, 2022-2025.Transboundary and emerging diseases · 2026Article
- Analysis on Cross-Species Transmission of Human-Suidae Zoonotic Viruses - Global, 1882-2022.China CDC weekly · 2025Article
- A SYBR green I-based multiplex real-time PCR for simultaneous detection of pseudorabies virus, porcine circovirus 3 and porcine parvovirus.BMC veterinary research · 2025Article
- Investigating the Presence and Genetic Variability of Porcine Circovirus Types 2 and 3 in Live Markets in Border Cities of Northeast China.Transboundary and emerging diseases · 2025Article
- Article
- Molecular characterization of canine circovirus based on the Capsid gene in Thailand.BMC veterinary research · 2024Article
- Investigation of porcine circovirus type 2 and porcine circovirus type 3 infections based on dual TaqMan fluorescent quantitative PCR method and genetic evolutionary analysis of these two viruses.Frontiers in microbiology · 2024Article
- Isolation and pathogenicity of porcine circovirus type 2 in mice from Guangxi province, China.Virology journal · 2023Article
- Detection and Complete Genomic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Porcine circovirus 3: a new challenge to explore.Frontiers in veterinary science · 2023Review
- Epidemiological and genetic characteristics of porcine circovirus 3 in 15 provinces and municipalities of China between 2016 and 2020.Virology journal · 2022Article
- Epidemiology and Genetic Diversity of PCV2 Reveals That PCV2e Is an Emerging Genotype in Southern China: A Preliminary Study.Viruses · 2022Article
- Nearly 20 Years of Genetic Diversity and Evolution of Porcine Circovirus-like Virus P1 from China.Viruses · 2022Article
- Genetic characterization of atypical porcine pestivirus from neonatal piglets with congenital tremor in Hubei province, China.Virology journal · 2022Article
- Reconstruction of the Evolutionary Origin, Phylodynamics, and Phylogeography of the Porcine Circovirus Type 3.Frontiers in microbiology · 2022Article
- Phylogenetic and codon usage analysis for replicase and capsid genes of porcine circovirus 3.Veterinary research communications · 2021Article
- Review
- The Main DNA Viruses Significantly Affecting Pig Livestock.Journal of veterinary research · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of a new circovirus (Porcine Circovirus 3, PCV3) has raised concern because its impact on swine health is not fully known. In Fujian Province in eastern China, even its circulating status and genetic characteristics are unclear. Here, we tested 127 tissue samples from swine from Fujian Province that presented respiratory symptoms. All of the PCV3 positive samples were negative for many other pathogens involved in respiratory diseases like PCV2, PRRSV, and CSFV, suggesting that PCV3 is potentially pathogenic. From phylogenetic analysis, PCV3 strains are divided into two main clades and five sub-clades; PCV3a-1, PCV3a-2, PCV3a-3, PCV3b-1, and PCV3b-2. Our identified strains belong to genotypes PCV3a-1, PCV3a-2, PCV3a-3, and PCV3b-2, indicating a high degree of genetic diversity of PCV3 in Fujian province until 2019. Interestingly, we found the time of the most recent common ancestor (tMRCA) of PCV3 was dated to the 1950s, and PCV3 has a similar evolutionary rate as PCV2 (the main epidemic genotypes PCV2b and PCV2d). In addition, positive selection sites N56D/S and S77T/N on the capsid gene are located on the PCV3 antigen epitope, indicating that PCV3 is gradually adaptive in swine. In summary, our results provide important insights into the epidemiology of PCV3.
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