Evidence map›Paper›PMID 31461676›Full record

ArticleNeuroImage2019

Autoidentification of perivascular spaces in white matter using clinical field strength T

Daniel L Schwartz, Erin L Boespflug, David L Lahna, Jeffrey Pollock, Natalie E Roese, Lisa C Silbert

Abstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation.medRxiv : the preprint server for health sciences · 2025
    Article
  10. Article
  11. Article
  12. Cerebral small vessel disease lesion segmentation methods: A systematic review.Cerebral circulation - cognition and behavior · 2025
    Review
  13. Review
  14. Fluctuation in body size and glymphatic system derangement in obesity.International journal of obesity (2005) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel L SchwartzOregon Health & Science University, Layton Aging and Alzheimer's Disease Center, Neurology, USA; Oregon Health & Science University, Advanced Imaging Research Center, USA. Electronic address: schwartd@ohsu.edu.
Erin L BoespflugOregon Health & Science University, Layton Aging and Alzheimer's Disease Center, Neurology, USA. Electronic address: boespfle@ohsu.edu.
David L LahnaOregon Health & Science University, Layton Aging and Alzheimer's Disease Center, Neurology, USA.
Jeffrey PollockOregon Health & Science University, Neuroradiology, USA.
Natalie E RoeseOregon Health & Science University, Layton Aging and Alzheimer's Disease Center, Neurology, USA.
Lisa C SilbertOregon Health & Science University, Layton Aging and Alzheimer's Disease Center, Neurology, USA; Portland Veterans Affairs Medical Center, Neurology, USA.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WOLTJER, RANDALL L · 1990 to 2019
$27.7M
Subcortical Vascular Cognitive Impairment-A Longitudinal Perfusion Imaging StudyR01AG036772 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI SILBERT, LISA C · 2011 to 2015
$1.6M
Characterizing enlarged perivascular spaces in Alzheimer's and vascular dementiaK01AG059842 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BOESPFLUG, ERIN LEIGH · 2018 to 2019
$241k
NCATS NIH HHS UL1 TR002369NIA NIH HHS K01 AG059842NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG036772NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122
6 · The paper itself

Abstract

Recent interest in enlarged perivascular spaces (ePVS) in the brain, which can be visualized on MRI and appear isointense to cerebrospinal fluid on all sequence weightings, has resulted in the necessity of reliable algorithms for automated segmentation to allow for whole brain assessment of ePVS burden. However, several publicly available datasets do not contain sequences required for recently published algorithms. This prospective study presents a method for identification of enlarged perivascular spaces (ePVS) in white matter using 3T T

Indexed as

AgingAlgorithmsAgedAged, 80 and overAlzheimer DiseaseCerebrovascular DisordersCohort StudiesDatasets as TopicFemaleGlymphatic SystemHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingAlzheimer’sEnlarged perivascular spaceMRISegmentationVascular diseaseVirchow-robin

Identifiers

PMID31461676
PMCPMC6819269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.