Evidence map›Paper›PMID 31461546›Full record

ArticlePsycho-oncology2019

Risk estimation, anxiety, and breast cancer worry in women at risk for breast cancer: A single-arm trial of personalized risk communication.

Zhuoer Xie, Neil Wenger, Annette L Stanton, Karen Sepucha, Celia Kaplan, Lisa Madlensky, David Elashoff, Jacqueline Trent, Antonia Petruse, Liliana Johansen and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psycho-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Anxiety Levels Among Women Undergoing Mammogram Screening.Current oncology (Toronto, Ont.) · 2025
    Article
  10. Review
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Physician management of thyroid cancer patients' worry.Journal of cancer survivorship : research and practice · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Zhuoer XieDepartment of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-1266-9804
Neil WengerDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Annette L StantonDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Karen SepuchaHealth Decision Sciences Center, Massachusetts General Hospital, Boston, Massachusetts.
Celia KaplanGeneral Internal Medicine, University of California, San Francisco, San Francisco, California.
Lisa MadlenskyDivision of Medical Genetics, University of California, San Diego, San Diego, California.
David ElashoffDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Jacqueline TrentDepartment of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Antonia PetruseDepartment of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Liliana JohansenDepartment of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Tracy LaytonDepartment of Biomedical Informatics, University of California, San Diego, San Diego, California.
Arash NaeimUCLA Center for SMART Health, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · USLos Angeles County Department of Health Services · USMassachusetts General Hospital · USSan Francisco General Hospital · USUniversity of California San Diego Medical Center · USUniversity of San Diego · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1TR001881NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA16042
6 · The paper itself

Abstract

objectiveElevated anxiety and breast cancer worry can impede mammographic screening and early breast cancer detection. Genetic advances and risk models make personalized breast cancer risk assessment and communication feasible, but it is unknown whether such communication of risk affects anxiety and disease-specific worry. We studied the effect of a personalized breast cancer screening intervention on risk perception, anxiety, and breast cancer worry.

methodsWomen with a normal mammogram but elevated risk for breast cancer (N = 122) enrolled in the Athena Breast Health risk communication program were surveyed before and after receiving a letter conveying their breast cancer risk and a breast health genetic counselor consultation. We compared breast cancer risk estimation, anxiety, and breast cancer worry before and after risk communication and evaluated the relationship of anxiety and breast cancer worry to risk estimation accuracy.

resultsWomen substantially overestimated their lifetime breast cancer risk, and risk communication somewhat mitigated this overestimation (49% pre-intervention, 42% post-intervention, 13% Gail model risk estimate, P < .001). Both general anxiety and breast cancer worry declined significantly after risk communication in women with high baseline anxiety. Baseline anxiety and breast cancer worry were essentially unrelated to risk estimation accuracy, but risk communication increased alignment of worry with accuracy of risk assessment.

conclusionsPersonalized communication about breast cancer risk was associated with modestly improved risk estimation accuracy in women with relatively low anxiety and less anxiety and breast cancer worry in women with higher anxiety. We detected no negative consequences of informing women about elevated breast cancer risk.

Indexed as

AnxietyAdultBreast NeoplasmsCommunicationEarly Detection of CancerFemaleGenetic CounselingGenetic Predisposition to DiseaseHealth BehaviorHumansMammographyMiddle AgedRisk AssessmentRisk FactorsSurveys and Questionnairesanxietybreast cancer worryoncologyperceived riskrisk communication

Identifiers

PMID31461546
PMCPMC6858926
OpenAlexW2970363534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.