ArticlePloS one2019
Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Pooled it
- Effects ofWorld journal of gastroenterology · 2024Trial
- Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift.Frontiers in immunology · 2020Trial
- The effects of different doses ofVeterinary and animal science · 2026Article
- Prebiotics and probiotics in animal nutrition: implications for food safety, sustainability, and circular production systems.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Review
- Effects of Compound Probiotics on Production Performance, Apparent Digestion Rate of Nutrients and Serum Index of Pigs at Different Stages.Animals : an open access journal from MDPI · 2026Article
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- Effects of Host-Specific Multi-Lactic Acid Bacterial Probiotics on Performance, Carcass Traits, Meat Quality, and Gut Microbiome in Fattening Pigs.Veterinary sciences · 2026Article
- Composition and nutritional role of gut microbiota on growth performance of pigs at different growth stages.The British journal of nutrition · 2026Article
- Dietary silicate: a biogenic strategy to enhance growth, gut health, and nutrient utilization in finishing pigs through low-carbon diets.Porcine health management · 2026Article
- Animal performance and gut microbiota of cattle as affected by the unfermented or fermented total mixed ration.BMC microbiology · 2026Article
- First insights into the intestinal microbiota of the endangered Angler Saddleback pig.PloS one · 2026Article
- Exploring the Multitude: A Review on Different Categorization of Probiotics.Probiotics and antimicrobial proteins · 2026Review
- The Role of Swine Gut Microbiota and Its Metabolites in Maintaining Intestinal Barrier Integrity and Mitigating Stress via the Gut-Brain Axis.Animals : an open access journal from MDPI · 2025Review
- Effects of adding Bacillus coagulans to the diet on diarrhea, gut microbiota, and metabolites in yak.BMC veterinary research · 2025Article
- The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals.Animals : an open access journal from MDPI · 2025Review
- A Review of Next-Generation Probiotics-As a Gateway to Biotherapeutics.Probiotics and antimicrobial proteins · 2025Review
- The Role of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Livestock and Poultry Gut Health: A Review.Metabolites · 2025Review
- Unraveling the composition and function of pig gut microbiome from metagenomics.Animal microbiome · 2025Review
- Swine Gut Lactic Acid Bacteria and Their Exopolysaccharides Differentially Modulate Toll-like Receptor Signaling Depending on the Agave Fructans Used as a Carbon Source.Animals : an open access journal from MDPI · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of probiotics in swine production is widely acknowledged as crucial. However, gaps still remain in the exact roles played by probiotics in modulation of gut microbiota and immune response. This study determined the roles of probiotic Lactobacillus plantarum strain JDFM LP11in gut microbiota modulation and immune response in weaned piglets. L. plantarum JDFM LP11 increased the population of lactic acid bacteria in feces and enhanced the development of villi in the small intestine. Metagenome analysis showed that microbial diversity and richness (Simpson, Shannon, ACE, Chao1) and the relative abundance of the Firmicutes were higher in weaned piglets fed probiotics. Five bacterial families were different in the relative abundance, especially; Prevotellaceae occupied the largest part of microbial community showed the most difference between two groups. Transcriptome analysis identified 25 differentially expressed genes using RNA-sequencing data of the ileum. Further gene ontology and immune DB analysis determined 8 genes associated with innate defense response and cytokine production. BPI, RSAD2, SLPI, LUM, OLFM4, DMBT1 and C6 genes were down-regulated by probiotic supplementation except PLA2G2A. PICRUSt analysis predicting functional profiling of microbial communities indicated branched amino acid biosynthesis and butyrate metabolism promoting gut development and health were increased by probiotics. Altogether, our data suggest that L. plantarum JDFM LP11 increases the diversity and richness in the microbial community, and attenuates the ileal immune gene expression towards gut inflammation, promoting intestinal development in weaned piglets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.