ArticleAging2019
Pathophysiology of aged lymphatic vessels.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 68 citations in OpenAlex.
- Numerical modeling of fluid exchange between a collecting lymphatic vessel and the surrounding tissue.Journal of mathematical biology · 2026Article
- What Do We Know About Immune System Aging from Human and Animal Studies?International journal of molecular sciences · 2026Review
- Artificial intelligence-based segmentation of perisinusoidal tissue along the superior sagittal sinus in human brain magnetic resonance imaging.Neuroradiology · 2026Article
- Rediscovering the Ciucci pathway: in-vivo evidence of a palmar lymphatic channel.Breast cancer research and treatment · 2026Article
- Ocular Lymphatics in Health and Disease.Diagnostics (Basel, Switzerland) · 2026Review
- Review
- The effect of prolonged complex decongestive therapy for lower limb secondary lymphedema.Journal of vascular surgery. Venous and lymphatic disorders · 2026Article
- High-yield isolation and characterization of microvascular niche cells from human full-thickness skin biopsies.Scientific reports · 2026Article
- Lymphatic vascular aging and age-related bone loss: current status and future perspectives.Frontiers in immunology · 2026Review
- Selected Pathological Criteria That Predict Low Rates of Axillary Lymph Node Metastases Regardless of Patient Age: A Single Institution Study.The breast journal · 2026Article
- Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study.Journal of surgical oncology · 2025Article
- NO-ergic mechanisms of age differences in photostimulation of lymphatic drainage, filtration, and clearance.Biomedical optics express · 2025Article
- Lymphedema and Axillary-Lateral Thoracic Vessel Juncture Irradiation: A Clinical Dilemma.European journal of breast health · 2025Article
- Skeletal muscle oxygenation and fluid content in upper extremity postthrombotic syndrome: a proof-of-concept study.Research and practice in thrombosis and haemostasis · 2025Article
- Predictors of the diuretic response in acute decompensated heart failure patients with severe aortic stenosis: sub-analysis of the LOHAS registry.Cardiovascular intervention and therapeutics · 2025Article
- Protective Factors Associated with Normal Lymphatic Function After Axillary Lymph Node Dissection for Breast Cancer Treatment.Annals of surgical oncology · 2025Article
- Article
- External Validation of a 5-Factor Risk Model for Breast Cancer-Related Lymphedema.JAMA network open · 2025Article
- Lymphatic-immune interactions in the musculoskeletal system.Frontiers in immunology · 2025Review
- Aging and physiological barriers: mechanisms of barrier integrity changes and implications for age-related diseases.Molecular biology reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphatic vessels maintain body homeostasis by recirculation of fluid and cells. Cell senescence induces lymphatic dysfunction. Impaired contractile function is caused by low muscle cell investiture and decrease of nitric oxide in aged lymphatic collectors, leading to poor drainage of lymph. Aging-induced loss of endothelial glycocalyx and production of inflammatory cytokines increases permeability of lymphatic vessels. In addition, aging-associated basal activation of mast cells delays immune response. In this review, we summarize the structural and pathological changes of aged lymphatic vessels, and discuss the underlying molecular mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.