ArticleJournal of neurophysiology2020
Changes in motoneuron excitability during voluntary muscle activity in humans with spinal cord injury.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Modulation of Forward Propulsion and Foot Dorsiflexion by Spinal and Muscular Stimulation During Human Stepping.Life (Basel, Switzerland) · 2026Article
- Non-invasive closed-loop spinal stimulation restores leg stepping control in humans with paraplegia.Brain : a journal of neurology · 2026Article
- Linking corticospinal tract activation and upper-limb motor control in adults with cerebral palsy.Developmental medicine and child neurology · 2024Article
- Changes in Corticospinal Excitability and Motor Control During Cerebellar Transcranial Direct Current Stimulation in Healthy Individuals.Cerebellum (London, England) · 2023Article
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury.eLife · 2022Article
- Paired pulse transcranial magnetic stimulation in the assessment of biceps voluntary activation in individuals with tetraplegia.Frontiers in human neuroscience · 2022Article
- Posteroanterior Cervical Transcutaneous Spinal Cord Stimulation: Interactions with Cortical and Peripheral Nerve Stimulation.Journal of clinical medicine · 2021Article
- Abnormal changes in motor cortical maps in humans with spinal cord injury.The Journal of physiology · 2021Article
- The Skeletal Muscle Emerges as a New Disease Target in Amyotrophic Lateral Sclerosis.Journal of personalized medicine · 2021Review
- Validity and Reliability of Surface Electromyography Features in Lower Extremity Muscle Contraction in Healthy and Spinal Cord-Injured Participants.Topics in spinal cord injury rehabilitation · 2021Article
- Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia.Experimental neurology · 2021Article
- The Potential of Corticospinal-Motoneuronal Plasticity for Recovery after Spinal Cord Injury.Current physical medicine and rehabilitation reports · 2020Article
- Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation in Humans with Tetraplegia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The excitability of resting motoneurons increases following spinal cord injury (SCI). The extent to which motoneuron excitability changes during voluntary muscle activity in humans with SCI, however, remains poorly understood. To address this question, we measured F waves by using supramaximal electrical stimulation of the ulnar nerve at the wrist and cervicomedullary motor-evoked potentials (CMEPs) by using high-current electrical stimulation over the cervicomedullary junction in the first dorsal interosseous muscle at rest and during 5 and 30% of maximal voluntary contraction into index finger abduction in individuals with chronic cervical incomplete SCI and aged-matched control participants. We found higher persistence (number of F waves present in each set) and amplitude of F waves at rest in SCI compared with control participants. With increasing levels of voluntary contraction, the amplitude, but not the persistence, of F waves increased in both groups but to a lesser extent in SCI compared with control participants. Similarly, the CMEP amplitude increased in both groups but to a lesser extent in SCI compared with controls. These results were also found at matched absolutely levels of electromyographic activity, suggesting that these changes were not related to decreases in voluntary motor output after SCI. F-wave and CMEP amplitudes were positively correlated across conditions in both groups. These results support the hypothesis that the responsiveness of the motoneuron pool during voluntary activity decreases following SCI, which could alter the generation and strength of voluntary muscle contractions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.