Evidence map›Paper›PMID 31461349›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls.

Robin S Chirackal, Muthuvel Jayachandran, Xiangling Wang, Samuel Edeh, Zejfa Haskic, Majuran Perinpam, Timothy M Halling, Ramila Mehta, Marcelino E Rivera, John C Lieske

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Robin S ChirackalDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Muthuvel JayachandranDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Xiangling WangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Samuel EdehDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Zejfa HaskicDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Majuran PerinpamDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Timothy M HallingDivision of Hematology Research, Mayo Clinic, Rochester, Minnesota.
Ramila MehtaHealth Sciences Research, Mayo Clinic, Rochester, Minnesota.
Marcelino E RiveraDepartment of Urology, Mayo Clinic, Rochester, Minnesota.
John C LieskeDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Primary HyperoxaluriaU54DK083908 · NIDDK · MAYO CLINIC ROCHESTER · PI MILLINER, DAWN SCHMAUTZ · 2009 to 2018
$12.3M
VISUALIZATION AND PATHOPHYSIOLOGY OF RENAL STONE PRECURSOR LESIONSU54DK100227 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 2013 to 2017
$6.3M
NIDDK NIH HHS U54 DK083908NIDDK NIH HHS U54 DK100227
6 · The paper itself

Abstract

Randall's plaque (RP; subepithelial calcification) appears to be an important precursor of kidney stone disease. However, RP cannot be noninvasively detected. The present study investigated candidate biomarkers associated with extracellular vesicles (EVs) in the urine of calcium stone formers (CSFs) with low (<5% papillary surface area) and high (≥5% papillary surface area) percentages of RP and a group of nonstone formers. RPs were quantitated via videotaping and image processing in consecutive CSFs undergoing percutaneous surgery for stone removal. Urinary EVs derived from cells of different nephron segments of CSFs (

Indexed as

Calcium OxalateAdultBiomarkersChemokine CCL2Extracellular SpaceFemaleHumansKidney CalculiLipocalin-2MaleNephronsOsteopontinBiomarkersCalcium OxalateCCL2 protein, humanChemokine CCL2LCN2 protein, humanLipocalin-2OsteopontinSPP1 protein, humanextracellular vesiclesmonocyte chemoattractant protein-1nephrolithiasisneutrophil gelatinase-associated lipocalinRandall’s plaqueurinary stone disease

Identifiers

PMID31461349
PMCPMC6962507
OpenAlexW2970715880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.