Evidence map›Paper›PMID 31461347›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Inactivation of

Leslie S Gewin, Megan E Summers, Julie W Harral, Christa F Gaskill, Stellor Nlandu Khodo, Surekha Neelisetty, Timothy M Sullivan, Katharina Hopp, J Jeffrey Reese, Dwight J Klemm and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Leslie S GewinDivision of Nephrology and Hypertension or Allergy, Department of Medicine, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Megan E SummersDivision of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Julie W HarralDivision of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Christa F GaskillDivision of Nephrology and Hypertension or Allergy, Department of Medicine, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Stellor Nlandu KhodoDivision of Nephrology and Hypertension or Allergy, Department of Medicine, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Surekha NeelisettyDivision of Nephrology and Hypertension or Allergy, Department of Medicine, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Timothy M SullivanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Katharina HoppDivision of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Aurora, Colorado.
J Jeffrey ReeseDivision of Nephrology or Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Dwight J KlemmDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Valentina KonDivision of Nephrology or Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Kevin C EssDivision of Pediatric Neurology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Wei ShiChildren's Hospital of Los Angeles, Developmental Biology and Regenerative Medicine Program at the Saban Research Institute, Los Angeles, California.
Susan M MajkaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.ORCID 0000-0002-1005-1552
Vanderbilt University · USUniversity of Colorado Anschutz Medical Campus · USVanderbilt University Medical Center · USNational Jewish Health · USChildren's Hospital of Los Angeles · USGates (United States) · US

Funding

Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Dwight J Klemm · 2018 to 2026
$13.5M
Role of Lung MSC in EmphysemaR01HL116597 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAJKA, SUSAN M · 2013 to 2021
$4.4M
TGF-beta Pathways that Protect Epithelia in Chronic Renal InjuryR01DK108968 · NIDDK · WASHINGTON UNIVERSITY · PI GEWIN, LESLIE S · 2016 to 2025
$3.7M
Pathogenic Mechanisms of Pulmonary LymphangioleiomyomatosisR01HL146541 · NHLBI · UNIVERSITY OF CINCINNATI · PI HENSKE, ELIZABETH P, SHI, WEI · 2019 to 2022
$2.6M
Lung MSC regulate angiogenesis and repair during fibrosisR01HL136449 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAJKA, SUSAN M · 2018 to 2021
$2.5M
Fate of Lung Stem Cells During Pulmonary DiseaseR01HL091105 · NHLBI · VANDERBILT UNIVERSITY · PI MAJKA, SUSAN M · 2009 to 2012
$1.5M
BLRD VA I01 BX003425NHLBI NIH HHS R01 HL091105NHLBI NIH HHS R01 HL116597NHLBI NIH HHS R01 HL136449NHLBI NIH HHS R01 HL146541NIA NIH HHS U54 AG062319NIDDK NIH HHS R01 DK108968
6 · The paper itself

Abstract

Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily G, Member 2Cell LineageFemaleFibrosisKidney Tubules, ProximalMaleMiceMyofibroblastsPolycystic Kidney DiseasesSelective Estrogen Receptor ModulatorsTamoxifenTuberous Sclerosis Complex 2 ProteinAbcg2 protein, mouseATP Binding Cassette Transporter, Subfamily G, Member 2Selective Estrogen Receptor ModulatorsTamoxifenTsc2 protein, mouseTuberous Sclerosis Complex 2 ProteinATP-binding cassette G2polycystic kidney diseasetuberous sclerosis complex 2

Identifiers

PMID31461347
PMCPMC6879939
OpenAlexW2970654037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.