Evidence map›Paper›PMID 31461343›Full record

ArticleAmerican journal of physiology. Cell physiology2019

Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action.

Vitor F Martins, Maedha Begur, Shivani Lakkaraju, Kristoffer Svensson, Ji Park, Byron Hetrick, Carrie E McCurdy, Simon Schenk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vitor F MartinsDepartment of Orthopaedic Surgery, University of California San Diego, La Jolla, California.ORCID 0000-0002-9060-1314
Maedha BegurDepartment of Orthopaedic Surgery, University of California San Diego, La Jolla, California.
Shivani LakkarajuDepartment of Orthopaedic Surgery, University of California San Diego, La Jolla, California.
Kristoffer SvenssonDepartment of Orthopaedic Surgery, University of California San Diego, La Jolla, California.
Ji ParkDepartment of Orthopaedic Surgery, University of California San Diego, La Jolla, California.
Byron HetrickDepartment of Human Physiology, University of Oregon, Eugene, Oregon.
Carrie E McCurdyDepartment of Human Physiology, University of Oregon, Eugene, Oregon.ORCID 0000-0003-1177-9040
Simon SchenkDepartment of Orthopaedic Surgery, University of California San Diego, La Jolla, California.ORCID 0000-0002-8224-3203
University of California San Diego · USUniversity of Oregon · US

Funding

SIRT1 and muscle insulin sensitivityR01AG043120 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHENK, SIMON · 2012 to 2016
$1.6M
The role of p300/CBP and acetylation towards skeletal muscle insulin actionF30DK115035 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTINS, VITOR FERNANDES · 2018 to 2020
$150k
NIDDK NIH HHS F30 DK115035
6 · The paper itself

Abstract

Whether the histone deacetylase (HDAC) and sirtuin families of protein deacetylases regulate insulin-stimulated glucose uptake, independent of their transcriptional effects, has not been studied. Our objective was to determine the nontranscriptional role of HDACs and sirtuins in regulation of skeletal muscle insulin action. Basal and insulin-stimulated glucose uptake and signaling and acetylation were assessed in L6 myotubes and skeletal muscle from C57BL/6J mice that were treated acutely (1 h) with HDAC (trichostatin A, panobinostat, TMP195) and sirtuin inhibitors (nicotinamide). Treatment of L6 myotubes with HDAC inhibitors or skeletal muscle with a combination of HDAC and sirtuin inhibitors increased tubulin and pan-protein acetylation, demonstrating effective impairment of HDAC and sirtuin deacetylase activities. Despite this, neither basal nor insulin-stimulated glucose uptake or insulin signaling was impacted. Acute reduction of the deacetylase activity of HDACs and/or sirtuins does not impact insulin action in skeletal muscle.

Indexed as

AnimalsCells, CulturedFemaleHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic AcidsInsulinMiceMice, Inbred C57BLMuscle, SkeletalMyoblastsHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic AcidsInsulintrichostatin Aglucose uptakehistone deacetylaseL6 myotubesirtuin

Identifiers

PMID31461343
PMCPMC6879879
OpenAlexW2971281494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.