Evidence map›Paper›PMID 31461191›Full record

ArticleProtein science : a publication of the Protein Society2019

Stability of Aβ-fibril fragments in the presence of fatty acids.

Wenhui Xi, Elliott K Vanderford, Qinxin Liao, Ulrich H E Hansmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Stability of Aβ-fibril fragments in the presence of fatty acids.Protein science : a publication of the Protein Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenhui XiDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma.ORCID 0000-0003-4272-7518
Elliott K VanderfordDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma.
Qinxin LiaoCollege of Chemistry, Beijing Normal University, Beijing, China.
Ulrich H E HansmannDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma.ORCID 0000-0002-0700-4835

Funding

Structural Transitions in Proteins and Protein AssembliesR01GM120634 · NIGMS · UNIVERSITY OF OKLAHOMA · PI HANSMANN, ULRICH H.E. · 2017 to 2020
$1.2M
Role of Lipid-derived Oligomer Strains in AD PhenotypesR56AG062292 · NIA · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI RANGACHARI, VIJAY · 2018 to 2018
$671k
NIA NIH HHS R56 AG062292NIGMS NIH HHS AG062292NIGMS NIH HHS GM120634NIGMS NIH HHS R01 GM120634
6 · The paper itself

Abstract

We consider the effect of lauric acid on the stability of various fibril-like assemblies of Aβ peptides. For this purpose, we have performed molecular dynamics simulations of these assemblies either in complex with lauric acid or without presence of the ligand. While we do not observe a stabilizing effect on Aβ

Indexed as

Amyloid beta-PeptidesFatty AcidsHumansModels, MolecularPeptide FragmentsProtein StabilityAmyloid beta-PeptidesFatty AcidsPeptide Fragmentsfibril stabilitymolecular dynamics simulation

Identifiers

PMID31461191
PMCPMC6798130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.