ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019
Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Gut microbiome differences in individuals with PTSD compared to trauma-exposed controls: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis.Frontiers in immunology · 2024Pooled it
- The microbiome and PTSD: a scoping review across preclinical and clinical studies.European journal of psychotraumatology · 2026Article
- Aripiprazole modulates splenic microbiota and immune response elicited by single prolonged stress in rats.Pharmacological reports : PR · 2026Article
- The Gut-Brain Axis in Post-Traumatic Stress Disorder: From Biological Mechanisms to Microbiome-Based Therapeutic Strategies-A Narrative Review.Microorganisms · 2026Review
- Review
- Integrating gut microbiota and violence exposure metrics to classify psychological distress in middle-aged adults.Communications medicine · 2026Article
- The role of gut microbiome in the pathophysiology of PTSD, depression, and anxiety disorders.Gut microbes reports · 2026Review
- From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD.Journal of eating disorders · 2025Review
- Exploring comorbidity networks in mild traumatic brain injury subjects through graph theory: a traumatic brain injury model systems study.BMC neurology · 2025Article
- I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms.The FEBS journal · 2025Review
- Biological, environmental, and psychological stress and the human gut microbiome in healthy adults.Scientific reports · 2025Article
- The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress.Neuroimmunomodulation · 2025Article
- Gut-brain axis in post-traumatic stress disorder: microbial - mediated mechanisms and new therapeutic approaches - A narrative review.Frontiers in pharmacology · 2025Review
- The microbiota-gut-brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention.Frontiers in aging neuroscience · 2025Review
- Balancing the Oral-Gut-Brain Axis with Diet.Nutrients · 2024Review
- High-throughput transcriptomics of 409 bacteria-drug pairs reveals drivers of gut microbiota perturbation.Nature microbiology · 2024Article
- Potential causal association between gut microbiome and posttraumatic stress disorder.Translational psychiatry · 2024Article
- Prebiotics as an adjunct therapy for posttraumatic stress disorder: a pilot randomized controlled trial.Frontiers in neuroscience · 2024Article
- Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review.Frontiers in neuroscience · 2024Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is associated with cirrhosis in veterans, and therapeutic results are suboptimal. An altered gut-liver-brain axis exists in cirrhosis due to hepatic encephalopathy (HE), but the added impact of PTSD is unclear. The aim of this study was to define linkages between gut microbiota and cognition in cirrhosis with/without PTSD. Cirrhotic veterans (with/without prior HE) underwent cognitive testing [PHES, inhibitory control test (ICT), and block design test (BDT)], serum lipopolysaccharide-binding protein (LBP) and stool collection for 16S rRNA microbiota composition, and predicted function analysis (PiCRUST). PTSD was diagnosed using DSM-V criteria. Correlation networks between microbiota and cognition were created. Patients with/without PTSD and with/without HE were compared. Ninety-three combat-exposed male veterans [ (58 yr, MELD 11, 34% HE, 31% combat-PTSD (42 no-HE/PTSD, 19 PTSD-only, 22 HE-only, 10 PTSD+HE)] were included. PTSD patients had similar demographics, alcohol history, MELD, but worse ICT/BDT, and higher antidepressant use and LBP levels. Microbial diversity was lower in PTSD (2.1 ± 0.5 vs. 2.5 ± 0.5,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.