Evidence map›Paper›PMID 31460455›Full record

ArticleACS omega2019

Biohybrid Electrospun Membrane for the Filtration of Ketoprofen Drug from Water.

Rossella Castagna, Stefano Donini, Paolo Colnago, Andrea Serafini, Emilio Parisini, Chiara Bertarelli

Abstract read
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Modulation of Albumin Esterase Activity by Warfarin and Diazepam.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Experimental and theoretical investigation of water-soluble silicon(IV) phthalocyanine and its interaction with bovine serum albumin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rossella CastagnaDipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, piazza L. da Vinci 32, 20133 Milano, Italy.
Stefano DoniniCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, via G. Pascoli 70/3, 20133 Milano, Italy.
Paolo ColnagoDipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, piazza L. da Vinci 32, 20133 Milano, Italy.
Andrea SerafiniDipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, Via L. Mancinelli, 7, 20131 Milano, Italy.
Emilio ParisiniCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, via G. Pascoli 70/3, 20133 Milano, Italy.
Chiara BertarelliDipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, piazza L. da Vinci 32, 20133 Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A current challenge in materials science and biotechnology is to express a specific and controlled functionality on the large interfacial area of a nanostructured material to create smart biohybrid systems for targeted applications. Here, we report on a biohybrid system featuring poly(vinyl alcohol) as the supporting synthetic polymer and bovine serum albumin as the biofunctional element. The optimal processing conditions to produce these self-standing composite membranes are determined, and the composition and distribution of the bioactive agent within the polymeric matrices are analyzed. A post-processing cross-linking using glutaraldehyde enables this functional membrane to be used as a chemical filter in aqueous environments. By demonstrating that our mats can remove large amounts of ketoprofen from water, we show that the combination of a BSA-induced biofunctionality with a nanostructured fibrous material allows for the development of an efficient biohybrid filtering device for the large and widely used family of nonsteroidal anti-inflammatory drugs (NSAIDs). The crystal structure of the complex between BSA and ketoprofen is determined for the first time and confirms the interaction between the two species.

Identifiers

PMID31460455
PMCPMC6704435

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.