Evidence map›Paper›PMID 31460309›Full record

ArticleACS omega2019

Fluorescent Supramolecular Assembly with Coronene Centers for Controlled DNA Condensation and Drug Delivery.

Yu-Hui Zhang, Jie Yu, Jie Wang, Li-Juan Wang, Wen-Han Yao, Siqintana Xin, Xianliang Sheng, Zeyu Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yu-Hui ZhangCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Jie YuSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, P. R. China.
Jie WangCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Li-Juan WangCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Wen-Han YaoCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Siqintana XinCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Xianliang ShengCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Zeyu GuoCollege of Science and College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Inner Mongolia Agricultural University · CNHunan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A multifunctional supramolecular assembly was successfully constructed by the host-guest complexation of doubly positively charged adamantane (ADA) with β-CD-modified hexabenzocoronene and the π-stacking of coronene with mitoxantrone, which was characterized by transmission electron microscopy, scanning electron microscopy, dynamic light-scattering, and zeta potential experiments. Possessing a small size and rigid backbone coronene center, the water-soluble biocompatible supramolecular assembly has intracellular imaging abilities. Moreover, after the ester group of ADA was hydrolyzed into a carboxyl group, the positively charged quaternary amine strand converted into a zwitterion structure, which realized the controlled plasmid DNA binding and release. Besides, the cytotoxicity experiments showed that the supramolecular assembly possesses slightly lower toxicity and a slightly higher anticancer activity than free drug. We believe that this work might present a convenient method for synergetic cancer treatment.

Identifiers

PMID31460309
PMCPMC6682016
OpenAlexW2957706264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.