Evidence map›Paper›PMID 31460302›Full record

ArticleACS omega2019

Naphthalimide-Based Template for Inhibitor Screening via Cross-Linking and In-Gel Fluorescence: A Case Study against HCA II.

Monisha Singha, Sayantani Roy, Ravina Moirangthem, Amit K Das, Amit Basak

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In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monisha SinghaDepartment of Chemistry, School of Bioscience, and Department of Biotechnology Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Sayantani RoyDepartment of Chemistry, School of Bioscience, and Department of Biotechnology Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Ravina MoirangthemDepartment of Chemistry, School of Bioscience, and Department of Biotechnology Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Amit K DasDepartment of Chemistry, School of Bioscience, and Department of Biotechnology Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Amit BasakDepartment of Chemistry, School of Bioscience, and Department of Biotechnology Indian Institute of Technology Kharagpur, Kharagpur 721302, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a rapid electrophoresis-based method for profiling of carbonic anhydrase inhibitors. In addition to the pharmacophore moiety intended for reversible interaction with a target enzyme, a fluorescent template with a built-in azide group for photoaffinity labeling is also included as a part of the inhibitor design. Following incubation and irradiation, gel electrophoresis with visualization under UV allows assessment of the efficiency of cross-linking. The relative efficiency of cross-linking of various probes can be regarded as a reflection of their inhibition potencies, an assumption supported by the trend in their IC

Identifiers

PMID31460302
PMCPMC6681978

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.