Evidence map›Paper›PMID 31460279›Full record

ArticleACS omega2019

pH-Labile Magnetic Nanocarriers for Intracellular Drug Delivery to Tumor Cells.

Santosh L Gawali, Kanhu C Barick, Neena G Shetake, Vasumathy Rajan, Badri N Pandey, N Naveen Kumar, K Indira Priyadarsini, Puthusserickal A Hassan

Abstract read
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Santosh L GawaliChemistry Division, Radiation Biology and Health Sciences Division, and Materials Science Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Kanhu C BarickChemistry Division, Radiation Biology and Health Sciences Division, and Materials Science Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Neena G ShetakeHomi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.
Vasumathy RajanChemistry Division, Radiation Biology and Health Sciences Division, and Materials Science Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Badri N PandeyHomi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.
N Naveen KumarChemistry Division, Radiation Biology and Health Sciences Division, and Materials Science Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
K Indira PriyadarsiniChemistry Division, Radiation Biology and Health Sciences Division, and Materials Science Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Puthusserickal A HassanChemistry Division, Radiation Biology and Health Sciences Division, and Materials Science Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the development of pH-labile ascorbic acid-coated magnetic nanocarriers (AMNCs) for effective delivery of the anticancer drug doxorubicin hydrochloride (DOX) to tumor cells. The uniqueness of this drug delivery system lies in the covalent conjugation of DOX through carbamate and hydrazone bonds, resulting in a slow and sustained drug release profile at different environmental acidities. X-ray diffraction and transmission electron microscopy analyses reveal the formation of crystalline single-phase Fe

Identifiers

PMID31460279
PMCPMC6682152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.