Evidence map›Paper›PMID 31459995›Full record

ArticleACS omega2019

MIL/Aptamer as a Nanosensor Capable of Resisting Nonspecific Displacement for ATP Imaging in Living Cells.

Jun Li, Yuedong Zhang, Zhen Zou, Zhihe Qing, Sheng Yang, Jianxiao Yang, Lihua Zhang, Feng Feng, Ronghua Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun LiSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China.
Yuedong ZhangSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China.
Zhen ZouSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China.
Zhihe QingSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China.
Sheng YangSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China.
Jianxiao YangCollege of Materials Science and Engineering, Hunan University, Changsha 410082, P. R. China.
Lihua ZhangCollege of Chemistry and Environmental Engineering, Shanxi Datong University, Datong, Shanxi 037009, P. R. China.
Feng FengCollege of Chemistry and Environmental Engineering, Shanxi Datong University, Datong, Shanxi 037009, P. R. China.
Ronghua YangSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent probes physisorbed on nanomaterials have emerged as a kind of useful and facile sensing platform for biological important molecules. However, nonspecific displacement in the physisorption systems is a non-negligible problem for the intracellular analysis. MIL (Materials of Institut Lavoisier), a subclass of metal-organic frameworks (MOFs), has high porosity, large surface area, and intriguing three-dimensional (3D) nanostructure with promising biological and biomedical applications such as molecular detection and drug delivery. Herein, we report MIL/aptamer-FAM as a nanosensor capable of resisting nonspecific displacement for intracellular adenosinetriphosphate (ATP) sensing and imaging. In this approach, by virtue of the remarkable quenching capability, high affinity of aptamers, and dramatic capability of resisting nonspecific displacement of 3D MIL-100, the assay and imaging of ATP in living cells were realized. Our results demonstrated that the MIL/aptamer-FAM nanosensor not only shows high selectivity for the detection of ATP in buffer but also is able to act as a "signal-on" nanosensor for specific imaging of ATP in living cells. The strategy reported here opens up a new way to develop MOF-based nanosensors for intracellular delivery and metabolite detection.

Identifiers

PMID31459995
PMCPMC6648595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.