Modeling Acid-Base by Minimizing Charge-Balance.

In this study, we show that equilibrium pH can be obtained for any specified fluid with any number of buffers and dissociations. This is done by root finding in the equation for charge balance. We demonstrate that this equation is monotonic in proton concentration for conceivable buffers. We show that the total charge on any buffer is a function of only the total buffer concentration and pH, given the thermodynamic dissociation constants. Using the Davies' equation as a placeholder for single-ion activity coefficients as a function of charge and ionic strength, we develop an iterative algorithm, whereby the apparent dissociation constants are updated from the thermodynamic dissociation constants, and from this, the equilibrium is also identified in the nonideal state. We show how this algebra leads to guaranteed conservation of both thermodynamic dissociation constants and total buffer concentrations because the distribution of buffer species is fixed by the updated dissociation constants, actual pH, and total buffer concentration. Strong ions are assumed to contribute fixed charges. In order to concentrate on the process of modeling the equilibrium pH alone, this algorithm is examined against a series of theoretical results in which the Davies' equation was given the same status. However, a large sample of clinical pH measurements is also examined. To enhance the practical utility, CO