Evidence map›Paper›PMID 31459682›Full record

ArticleACS omega2019

Nitrosobenzene: Reagent for the Mitsunobu Esterification Reaction.

Adam Pokluda, Michal Kohout, Josef Chudoba, Martin Krupička, Radek Cibulka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Adam PokludaDepartment of Organic Chemistry and Central Laboratories, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
Michal KohoutDepartment of Organic Chemistry and Central Laboratories, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
Josef ChudobaDepartment of Organic Chemistry and Central Laboratories, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
Martin KrupičkaDepartment of Organic Chemistry and Central Laboratories, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
Radek CibulkaDepartment of Organic Chemistry and Central Laboratories, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
University of Chemistry and Technology, Prague · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitrosobenzene has been demonstrated to participate in the Mitsunobu reaction in an analogous manner to dialkyl azodicarboxylates. The protocol using nitrosobenzene and triphenylphosphine (1:1) under mild conditions (0 °C) provides the ester derivatives of aliphatic and aromatic acids using various alcohols in moderate yield and with good enantioselectivity, giving the desired products predominantly with an inversion of configuration. The proposed mechanism, which is analogous to that observed using dialkyl azodicarboxylates, involves a nitrosobenzene-triphenylphosphine adduct and an alkoxytriphenylphosphonium ion and was supported by density functional theory calculations,

Identifiers

PMID31459682
PMCPMC6648318
OpenAlexW2922395001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.