Evidence map›Paper›PMID 31459615›Full record

ArticleACS omega2019

Bacteria-Responsive Single and Core-Shell Nanofibrous Membranes Based on Polycaprolactone/Poly(ethylene succinate) for On-Demand Release of Biocides.

Zahra Abdali, Sarvesh Logsetty, Song Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Overview of Antimicrobial Biodegradable Polyester-Based Formulations.International journal of molecular sciences · 2023
    Review
  3. Review
  4. On-Demand Drug Delivery Systems Using Nanofibers.Nanomaterials (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zahra AbdaliBiomedical Engineering, Faculty of Engineering, Director of Manitoba Firefighters Burn Unit, Professor in the Departments of Surgery and Psychiatry, Rady Faculty of Health Sciences, Department of Biosystems Engineering, and Department of Medical Microbiology, University of Manitoba, Winnipeg R3T 2N2, Canada.
Sarvesh LogsettyBiomedical Engineering, Faculty of Engineering, Director of Manitoba Firefighters Burn Unit, Professor in the Departments of Surgery and Psychiatry, Rady Faculty of Health Sciences, Department of Biosystems Engineering, and Department of Medical Microbiology, University of Manitoba, Winnipeg R3T 2N2, Canada.
Song LiuBiomedical Engineering, Faculty of Engineering, Director of Manitoba Firefighters Burn Unit, Professor in the Departments of Surgery and Psychiatry, Rady Faculty of Health Sciences, Department of Biosystems Engineering, and Department of Medical Microbiology, University of Manitoba, Winnipeg R3T 2N2, Canada.
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional antibacterial dressings continuously elute biocides, even if there are no bacteria. This unneeded release can cause cytotoxicity, increase costs, and delay healing. We designed a bacteria-responsive nanofibrous wound dressing, which can be degraded in the presence of bacteria to release antimicrobial agents. A model biocide, benzyl dimethyl tetradecyl ammonium chloride (BTAC), was incorporated into bacteria-degradable polymers [polycaprolactone and poly(ethylene succinate)] in two ways: evenly distributed inside the polymers as single nanofibers and encapsulated in a core surrounded by the same polymers as core-shell nanofibers. Because of bacterial activity (both lipase secretion and acidic pH), degradation of the fibers was facilitated and caused the release of incorporated BTAC. BTAC-loaded single and core-shell nanofibers presented >1 log reduction of both

Identifiers

PMID31459615
PMCPMC6647954
OpenAlexW2916851306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.