Evidence map›Paper›PMID 31459579›Full record

ArticleACS omega2019

Electrospun Conducting and Biocompatible Uniaxial and Core-Shell Fibers Having Poly(lactic acid), Poly(ethylene glycol), and Polyaniline for Cardiac Tissue Engineering.

Paula T Bertuoli, Jesús Ordoño, Elaine Armelin, Soledad Pérez-Amodio, Alessandra F Baldissera, Carlos A Ferreira, Jordi Puiggalí, Elisabeth Engel, Luis J Del Valle, Carlos Alemán

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 109 citations in OpenAlex.

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  9. Advances in cardiac tissue engineering and heart-on-a-chip.Journal of biomedical materials research. Part A · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Paula T BertuoliPrograma de Pós-Graduação em Engenharia de Minas, Metalúrgica e Materiais (PPGE3M), and Departamento de Materiais (DEMAT), Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, 9500, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
Jesús OrdoñoInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Elaine ArmelinDepartament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain.
Soledad Pérez-AmodioInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Alessandra F BaldisseraPrograma de Pós-Graduação em Engenharia de Minas, Metalúrgica e Materiais (PPGE3M), and Departamento de Materiais (DEMAT), Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, 9500, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
Carlos A FerreiraPrograma de Pós-Graduação em Engenharia de Minas, Metalúrgica e Materiais (PPGE3M), and Departamento de Materiais (DEMAT), Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves, 9500, 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
Jordi PuiggalíDepartament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain.
Elisabeth EngelInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Luis J Del ValleDepartament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain.
Carlos AlemánDepartament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain.
Universitat Politècnica de Catalunya · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electroactive and biocompatible fibrous scaffolds have been prepared and characterized using polyaniline (PAni) doped with dodecylbenzenesulfonic acid (DBSA) combined with poly(lactic acid) (PLA) and PLA/poly(ethylene glycol) (PEG) mixtures. The composition of simple and core-shell fibers, which have been obtained by both uniaxial and coaxial electrospinning, respectively, has been corroborated by Fourier-transform infrared and micro-Raman spectroscopies. Morphological studies suggest that the incorporation of PEG enhances the packing of PLA and PAni chains, allowing the regulation of the thickness of the fibers. PAni and PEG affect the thermal and electrical properties of the fibers, both decreasing the glass transition temperature and increasing the electrical conductivity. Interestingly, the incorporation of PEG improves the PAni-containing paths associated with the conduction properties. Although dose response curves evidence the high cytotoxicity of PAni/DBSA, cell adhesion and cell proliferation studies on PLA/PAni fibers show a reduction of such harmful effects as the conducting polymer is mainly retained inside the fibers through favorable PAni···PLA interactions. The incorporation of PEG into uniaxial fibers resulted in an increment of the cell mortality, which has been attributed to its rapid dissolution into the culture medium and the consequent enhancement of PAni release. In opposition, the delivery of PAni decreases and, therefore, the biocompatibility of the fibers increases when a shell coating the PAni-containing system is incorporated through coaxial electrospinning. Finally, morphological and functional studies using cardiac cells indicated that these fibrous scaffolds are suitable for cardiac tissue engineering applications.

Identifiers

PMID31459579
PMCPMC6648110
OpenAlexW2916339003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.