ArticleACS omega2018
Tandem Alkylation-Second-Order Asymmetric Transformation Protocol for the Preparation of Phenylalanine-Type Tailor-Made α-Amino Acids.
Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Strategies for chiral separation: from racemate to enantiomer.Chemical science · 2023Review
- Asymmetric Synthesis of Tailor-Made Amino Acids Using Chiral Ni(II) Complexes of Schiff Bases. An Update of the Recent Literature.Molecules (Basel, Switzerland) · 2020Review
- Preparative Method for Asymmetric Synthesis of (Molecules (Basel, Switzerland) · 2019Article
- Optical Resolution of Rimantadine.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
8 authors.
Funding
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Abstract
In this work, we disclose an advanced general process for the synthesis of tailor-made α-amino acids (α-AAs) via tandem alkylation-second-order asymmetric transformation. The first step is the alkylation of the chiral Ni(II) complex of glycine Schiff base, which is conducted under mild phase-transfer conditions allowing the structural construction of target α-AAs. The second step is based on the methodologically rare second-order asymmetric transformation, resulting in nearly complete precipitation of the corresponding (S
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