Evidence map›Paper›PMID 31459059›Full record

ArticleACS omega2018

Array-Based Protein Sensing Using an Aggregation-Induced Emission (AIE) Light-Up Probe.

Huyeon Choi, Sangpil Kim, Seungho Lee, Chaekyu Kim, Ja-Hyoung Ryu

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Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huyeon ChoiDepartment of Chemistry, Ulsan National Institute of Science and Technology, UNIST-gil 50, Ulsan 44919, South Korea.
Sangpil KimDepartment of Chemistry, Ulsan National Institute of Science and Technology, UNIST-gil 50, Ulsan 44919, South Korea.
Seungho LeeDepartment of Chemistry, Ulsan National Institute of Science and Technology, UNIST-gil 50, Ulsan 44919, South Korea.
Chaekyu KimDepartment of Chemistry, Ulsan National Institute of Science and Technology, UNIST-gil 50, Ulsan 44919, South Korea.
Ja-Hyoung RyuDepartment of Chemistry, Ulsan National Institute of Science and Technology, UNIST-gil 50, Ulsan 44919, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein detection and identification are important for the diagnosis of diseases; however, the development of facile sensing probes still remains challenging. Here, we present an array-based "turn on" protein-sensing platform capable of detecting and identifying proteins using aggregation-induced emission luminogens (AIEgens). The water-soluble AIEgens in which fluorescence was initially turned off showed strong fluorescence in the presence of nanomolar concentrations of proteins via restriction of the intramolecular rotation of the AIEgens. The binding affinities between the AIEgens and proteins were associated with various chemical functional groups on AIEgens, resulting in distinct fluorescent-signal outcomes for each protein. The combined fluorescence outputs provided sufficient information to detect and discriminate proteins of interest by linear discriminant analysis. Furthermore, the array-based sensor enabled classification of different concentrations of specific proteins. These results provide novel insight into the use of the AIEgens as a new type of sensing probe in array-based systems.

Identifiers

PMID31459059
PMCPMC6644794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.