ArticleACS omega2018
Effect of Substrate Number Fluctuations in Stochastic Enzyme Kinetics.
Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional studies on enzyme kinetics assume that the substrate concentration remains constant. However, for catalytic reactions taking place in intracellular compartments, the substrate molecules are fed in and out of the compartment and are catalyzed into product molecules within the compartment. In this work, we use a chemical master equation approach to study the stochastic kinetics of a single enzyme for different reaction pathways with one or more intermediate states. We obtain velocity expressions that deviate from the Michaelis-Menten expression. We study the coefficient of variation, which is a measure of the noise strength as a function of the mean substrate concentration for systems where there is influx or/and outflux of substrate molecules. Our results show that the noise strength decreases with the increase in the substrate concentration and finally remains the same when the substrate is present in abundance.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.