Evidence map›Paper›PMID 31458298›Full record

ArticleACS omega2018

Tristearin as a Model Cuticle for High-Throughput Screening of Agricultural Adjuvant Systems.

Graham R Webster, Nicole B Bisset, David M Cahill, Peter Jones, Andrew Killick, Adrian Hawley, Ben J Boyd

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Graham R WebsterDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Nicole B BissetDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
David M CahillSchool of Life and Environmental Sciences, Deakin University, Geelong Campus at Waurn Ponds, Geelong, Victoria 3217, Australia.
Peter JonesVictorian Chemicals Pty, 83 Maffra Street, Coolaroo, Victoria 3048, Australia.
Andrew KillickVictorian Chemicals Pty, 83 Maffra Street, Coolaroo, Victoria 3048, Australia.
Adrian HawleySAXS/WAXS Beamline, Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia.
Ben J BoydDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Molecular Research Institute · USVictorian Bar · AUAustralian Synchrotron · AUDeakin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widely varied compositions and structures of plant cuticles create problems in the identification of suitable model systems for laboratory testing of adjuvants. We have compared the behavior of an extracted cuticle wax with tristearin, a well characterized crystalline triglyceride, which we propose as a model cuticle for ranking new adjuvant systems for their propensity to disrupt the cuticle barrier. The interaction of adjuvant products and their components with the extracted cuticle wax and tristearin was determined using differential scanning calorimetry and small angle X-ray scattering approaches. The interaction of the additive with tristearin caused a concentration-dependent change in the crystallite level, and correlated between the extracted wax and tristearin. Tristearin was subsequently used to compare the effectiveness of a range of adjuvant products and their major components. This approach has utility to quantify the effects of adjuvant components and enable more judicious selection of adjuvant candidates to progress to plant trials.

Identifiers

PMID31458298
PMCPMC6643694
OpenAlexW2903257193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.