Evidence map›Paper›PMID 31457922›Full record

ArticleACS omega2018

Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents.

Francis T Hane, Ashvin Fernando, Braedan R J Prete, Brianna Peloquin, Scott Karas, Sauradip Chaudhuri, Simrun Chahal, Yurii Shepelytskyi, Alanna Wade, Tao Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Review
  3. Article
  4. Cyclodextrin-Based Contrast Agents for Medical Imaging.Molecules (Basel, Switzerland) · 2020
    Review
  5. Article
  6. Analytical chemistry · 2020
    Article
  7. Rotaxane Probes for the Detection of Hydrogen Peroxide byAngewandte Chemie (International ed. in English) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Francis T HaneDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Ashvin FernandoDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
Braedan R J PreteDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Brianna PeloquinDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
Scott KarasDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
Sauradip ChaudhuriDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
Simrun ChahalDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Yurii ShepelytskyiDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Alanna WadeDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Tao LiDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Brenton DeBoefDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
Mitchell S AlbertDepartment of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Lakehead University · CAUniversity of Rhode Island · USThunder Bay Regional Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced

Identifiers

PMID31457922
PMCPMC6641221
OpenAlexW2784321155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.