ArticleACS omega2017
Total Synthesis of (±)-Allocolchicine and Its Analogues Using Co-Catalyzed Alkyne [2 + 2 + 2]-Cyclotrimerization.
Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Improving the odds of success in antitumoral drug development using scoring approaches towards heterocyclic scaffolds.Oncology reports · 2020Article
- Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation.Beilstein journal of organic chemistry · 2019Article
- Air-Stable CpCoEuropean journal of organic chemistry · 2018Article
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Authors and funding
2 authors.
Funding
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Abstract
The total synthesis of (±)-allocolchicine has been completed by employing cobalt-catalyzed alkyne [2 + 2 + 2]-cyclotrimerization as the key reaction. The essential diyne has been synthesized from easily available 3,4,5-trimethoxybenzaldehyde following simple chemical transformations. In general, the cycloaddition gave a mixture of C(9) and C(10) isomers thus allowing the synthesis of both allocolchicine and its C(10)-carboxylate. Because this cycloaddition was employed at the penultimate stage, it allowed the synthesis of various analogues having the diverse functionality at C(9) and/or C(10) of ring C.
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Registered trials
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