Evidence map›Paper›PMID 31457107›Full record

ArticleNature human behaviour2018

Social and population health science approaches to understand the human microbiome.

Pamela Herd, Alberto Palloni, Federico Rey, Jennifer B Dowd

Open access · greenAbstract read
In one paragraph

Article in Nature human behaviour, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. A Meta-analysis of Gut Microbiota in Children with Autism.Journal of autism and developmental disorders · 2022
    Pooled it
  2. Observational
  3. Review
  4. Examining the healthy human microbiome concept.Nature reviews. Microbiology · 2025
    Review
  5. Article
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  19. Article
  20. Probiotics and Psychobiotics: the Role of Microbial Neurochemicals.Probiotics and antimicrobial proteins · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Pamela HerdMcCourt School of Public Policy, Georgetown University, Washington, DC, USA. ph627@georgetown.edu.ORCID http://orcid.org/0000-0002-0137-5846
Alberto PalloniDepartment of Sociology, University of Wisconsin-Madison, Madison, WI, USA.
Federico ReyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-0239-7780
Jennifer B DowdDepartment of Global Health and Social Medicine, Kings College London, London, UK.
University of Wisconsin–Madison · USGeorgetown University · USThe Graduate Center, CUNY · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Statistical Data Enclave CoreP30AG017266 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1999 to 2026
$17.0M
A Longitudinal Resource for Genetic Research in Behavioral & Health SciencesR01AG041868 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FREESE, JEREMY J, HAUSER, ROBERT M. · 2013 to 2017
$3.0M
The representative microbiome: social determinants and tools for population researchR21AI121784 · NIAID · GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY · PI DOWD, JENNIFER BEAM · 2016 to 2017
$446k
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NIAID NIH HHS R21 AI121784NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG041868
6 · The paper itself

Abstract

The microbiome is now considered our 'second genome' with potentially comparable importance to the genome in determining human health. There is, however, a relatively limited understanding of the broader environmental factors, particularly social conditions, that shape variation in human microbial communities. Fulfilling the promise of microbiome research - particularly the microbiome's potential for modification - will require collaboration between biologists and social and population scientists. For life scientists, the plasticity and adaptiveness of the microbiome calls for an agenda to understand the sensitivity of the microbiome to broader social environments already known to be powerful predictors of morbidity and mortality. For social and population scientists, attention to the microbiome may help answer nagging questions about the underlying biological mechanisms that link social conditions to health. We outline key substantive and methodological advances that can be made if collaborations between social and population health scientists and life scientists are strategically pursued.

Indexed as

Interdisciplinary CommunicationMicrobiotaHumansInterdisciplinary ResearchPublic HealthSocial Medicine

Identifiers

PMID31457107
PMCPMC6711373
OpenAlexW2896689093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.