ArticleScience advances2019
Off-on switching of enzyme activity by near-infrared light-induced photothermal phase transition of nanohybrids.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 83 citations in OpenAlex.
- Supramolecularly gated enzymes: On-demand activity switching via host-guest competition for precision tumor therapy.Materials today. Bio · 2026Article
- Recent progress and future perspectives of infrared light-based technology in ophthalmology.Frontiers in medicine · 2026Review
- Single-Molecule DNA Tweezers Enable Programmable Control of Enzyme Activity via Arbitrary Molecular Cues.Angewandte Chemie (International ed. in English) · 2025Article
- Targeting Hyperglycemic Bone Pre-Metastatic Niche for Breast Cancer Bone Metastasis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- Shape morphing of hydrogels by harnessing enzyme enabled mechanoresponse.Nature communications · 2024Article
- Design of Nanodrug Delivery Systems for Tumor Bone Metastasis.Current pharmaceutical design · 2024Review
- Current Strategies for Real-Time Enzyme Activation.Biomolecules · 2022Review
- Modulation of Transaminase Activity by Encapsulation in Temperature-Sensitive Poly(N-acryloyl glycinamide) Hydrogels.Chembiochem : a European journal of chemical biology · 2021Article
- Article
- Recent advancements in enzyme-mediated crosslinkable hydrogels:APL bioengineering · 2021Review
- A DNA nanopillar as a scaffold to regulate the ratio and distance of mimic enzymes for an efficient cascade catalytic platform.Chemical science · 2020Article
- Full Thermal Switching of Enzymes by Thermoresponsive Poly(2-oxazoline)-Based Enzyme Inhibitors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The off-on manipulation of enzyme activity is a challenging task. We report a new strategy for reversible off-on control of enzyme activity by near-infrared light. Enzymes acting on macromolecular substrates are embedded with an ultrasmall platinum nanoparticle and decorated with thermoresponsive copolymers, which exhibit upper critical solution temperature (UCST) behavior. The polymer-enzyme nanohybrids form microscale aggregates in solution below the UCST to prevent macromolecular substrates from approaching the enzymes and thus inhibit the enzyme activity, and they disassemble above the UCST to reactivate the enzyme. Upon near-infrared irradiation, platinum nanoparticles inside the enzymes generate heat through a photothermal effect to cause phase transition of the copolymers. Therefore, we can reversibly switch off and on the activities of three enzymes acting on polysaccharide, protein, and plasmid. The enzyme activities are increased by up to 61-fold after laser irradiation. This study provides a facile and efficient method for off-on control of enzyme activity.
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