ArticleScience advances2019
Bcl11b prevents fatal autoimmunity by promoting T
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Comprehensive Transcriptomic and Proteomic Analysis of Severe Pressure Ulcer Patients Identifies Molecular Signatures Associated with Impaired T Cell Function.Biomolecules · 2025Article
- Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- T and NK cell functionality in a patient harboring heterozygous novel BCL11B p.Asp632fsAla∗91 and STX11 p.R129P mutations.Heliyon · 2025Article
- Plasma Exosomal miR-17-5p Regulates Macrophage Polarization by Targeting Bcl11b in Sepsis-Induced Lung Injury.Journal of inflammation research · 2025Article
- Functional overlap of inborn errors of immunity and metabolism genes defines T cell metabolic vulnerabilities.Science immunology · 2024Article
- Identification of key genes with abnormal RNA methylation modification and selected m6A regulators in ankylosing spondylitis.Immunity, inflammation and disease · 2024Article
- Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis.Brain : a journal of neurology · 2024Article
- The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene.Nucleic acids research · 2024Article
- Efferocytosis in dendritic cells: an overlooked immunoregulatory process.Frontiers in immunology · 2024Review
- Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells.The Journal of clinical investigation · 2023Article
- The role of transcription factors in shaping regulatory T cell identity.Nature reviews. Immunology · 2023Review
- Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8Science immunology · 2023Article
- Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease.Signal transduction and targeted therapy · 2022Article
- MTUS1 is a promising diagnostic and prognostic biomarker for colorectal cancer.World journal of surgical oncology · 2022Article
- Case report: A novel truncating variant ofFrontiers in pediatrics · 2022Article
- Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment.Biophysical journal · 2021Review
- Article
- The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.Science immunology · 2021Article
- Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2021Article
- Epigenetic Dynamics in the Function of T-Lineage Regulatory Factor Bcl11b.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Theodore T DrashanskyDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6215-1232
Eric HelmDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6128-5204
Zhiguang HuoDepartment of Biostatistics, College of Medicine, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-8032-4392
Nina CurkovicDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-2200-4988
Preet KumarDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Xiaoping LuoDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-3873-6422
Upasana ParthasarathyDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-8059-3958
Ashley ZunigaDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-0321-674X
Jonathan J ChoDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kyle J LorentsenDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Zhiwei XuDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Mohammad UddinDepartment of Microbiology and Immunology, Albany Medical College, Albany, NY 12208, USA.
Safiehkhathoon MoshkaniDepartment of Microbiology and Immunology, Albany Medical College, Albany, NY 12208, USA.ORCID 0000-0002-2650-6320
Liang ZhouDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
Dorina AvramDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-1254-1122
University of Florida · USUniversity of Florida Health · USAlbany Medical Center Hospital · US
Funding
Role of Bcl11b in CD4+ T cells and innate lymphoid cellsR01AI067846 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2007 to 2023
$6.2MRegulation of Gut Innate Lymphoid Cells by AhrR01AI132391 · NIAID · UNIVERSITY OF FLORIDA · PI Liang Zhou · 2017 to 2026
$4.8MBASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3MTraining Program in Regenerative MedicineT32DK074367 · NIDDK · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2007 to 2022
$2.9MROLE OF AHR IN T LYMPHOCYTE DEVELOPMENT AND FUNCTIONR01DK105562 · NIDDK · UNIVERSITY OF FLORIDA · PI ZHOU, LIANG · 2015 to 2019
$1.8MRegulation of CD4 T cell Development and Function by BCL11B Transcription FactorR01AI078273 · NIAID · ALBANY MEDICAL COLLEGE · PI AVRAM, DORINA · 2008 to 2012
$1.2MTranscriptional control of genes implicated in suppression function of Treg cellsR21AI131205 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2017 to 2018
$419kBCL11B in Immune RegulationR56AI078273 · NIAID · ALBANY MEDICAL COLLEGE · PI AVRAM, DORINA · 2013 to 2013
$205kNIAID NIH HHS R01 AI067846NIAID NIH HHS R01 AI078273NIAID NIH HHS R01 AI132391NIAID NIH HHS R21 AI131205NIAID NIH HHS R56 AI078273NIAID NIH HHS T32 AI007110NIDDK NIH HHS R01 DK105562NIDDK NIH HHS T32 DK074367
Abstract
Regulatory T (T
Indexed as
AutoimmunityAnimalsCD4-Positive T-LymphocytesCell LineageColitisEncephalomyelitis, Autoimmune, ExperimentalFemaleFetusForkhead Transcription FactorsHumansKaplan-Meier EstimateMaleMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutBcl11b protein, mouseForkhead Transcription FactorsRepressor ProteinsTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.