ArticleScience advances2019
A common neural signature of brain injury in concussion and subconcussion.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Uncovering the hidden effects of repetitive subconcussive head impact exposure: A mega-analytic approach characterizing seasonal brain microstructural changes in contact and collision sports athletes.Human brain mapping · 2024Pooled it
- Head Impact Research Using Inertial Sensors in Sport: A Systematic Review of Methods, Demographics, and Factors Contributing to Exposure.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Diffusion MRI as a complementary assessment to cognition, emotion, and motor dysfunction after sports-related concussion: a systematic review and critical appraisal of the literature.Brain imaging and behavior · 2021Pooled it
- Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group.Brain imaging and behavior · 2021Pooled it
- Characteristic patterns of white matter tract injury in sport-related concussion: An image based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026Review
- Non-concussive head impacts sustained during American football correlate with changes in gut microbiome diversity and composition.PloS one · 2026Article
- Noninvasive mapping of shear strain predicts the anatomical distribution of mild traumatic brain injury.NeuroImage. Clinical · 2026Article
- Article
- Smooth Pursuit Velocity After a Season of Repetitive Head Impacts in American Football Players.JAMA ophthalmology · 2025Article
- Longitudinal changes in frontopolar cortex activity during postural tasks in collegiate ice hockey athletes.Neurophotonics · 2025Article
- MR elastography-based detection of impaired skull-brain mechanical decoupling performance in response to repetitive head impacts.European radiology · 2025Article
- Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy.Molecular neurodegeneration · 2025Review
- Investigating the Utility of the BrainEye Smartphone Eye Tracking Application and Platform in Concussion Management.Sports medicine - open · 2025Article
- Group-specific discriminant analysis enhances detection of sex differences in brain functional network lateralization.GigaScience · 2025Article
- Assessment of the brain impact of soccer heading using pupillary light reflex.Frontiers in neurology · 2025Article
- Functional Vision Questionnaire Detects Near Triad Impairments in Adolescent Athletes With Concussion History.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2024Article
- An objective neurophysiological study of subconcussion in female and male high school student athletes.Scientific reports · 2024Article
- Concussion in Female Athletes of Contact Sports: A Scoping Review.Orthopaedic journal of sports medicine · 2024Article
- Strain concentration drives the anatomical distribution of injury in acute and chronic traumatic brain injury.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
The midbrain is biomechanically susceptible to force loading from repetitive subconcussive head impacts (RSHI), is a site of tauopathy in chronic traumatic encephalopathy (CTE), and regulates functions (e.g., eye movements) often disrupted in concussion. In a prospective longitudinal design, we demonstrate there are reductions in midbrain white matter integrity due to a single season of collegiate football, and that the amount of reduction in midbrain white matter integrity is related to the amount of rotational acceleration to which players' brains are exposed. We then replicate the observation of reduced midbrain white matter integrity in a retrospective cohort of individuals with frank concussion, and further show that variance in white matter integrity is correlated with levels of serum-based tau, a marker of blood-brain barrier disruption. These findings mean that noninvasive structural MRI of the midbrain is a succinct index of both clinically silent white matter injury as well as frank concussion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.