Evidence map›Paper›PMID 31456916›Full record

ArticleInternational journal of ophthalmology2019

Dynamic changes of activator protein 1 and collagen I expression in the sclera of myopia guinea pigs.

Xin Zhan, Zi-Cheng Zhu, Si-Qin Sun, Yue-Chun Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The Duality of Collagens in Metastases of Solid Tumors.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Effects ofExperimental and therapeutic medicine · 2021
    Article
  5. IMI 2021 Yearly Digest.Investigative ophthalmology & visual science · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xin ZhanDepartment of Ophthalmology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
Zi-Cheng ZhuDepartment of Ophthalmology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
Si-Qin SunDepartment of Ophthalmology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
Yue-Chun WenDepartment of Ophthalmology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
Anhui Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the dynamic changes of activator protein 1 (AP1) and collagen I expression in the sclera of form-deprivation myopic model in guinea pigs.

methodsA form-deprivation myopic model in guinea pigs were established with the left eye covered for 2 to 6wk (FDM group). Normal control group (

resultsAfter 0, 2, 4, 6wk, and 4/-1wk of form-deprivation, the diopter in the FDM group was gradually changed (2.08±0.31, -1.23±0.68, -4.17±0.58, -7.07±0.55, and -2.67±0.59 D, respectively,

conclusionAP1 may be an important transcription factor involved in the regulation of collagen I synthesis and degradation during myopic scleral remodeling.

Indexed as

activator protein 1collagen Iform deprivation myopiaguinea pigsclera remodeling

Identifiers

PMID31456916
PMCPMC6694059
OpenAlexW2968421208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.