Evidence map›Paper›PMID 31456797›Full record

ArticleFrontiers in immunology2019

Changes in the NK Cell Repertoire Related to Initiation of TB Treatment and Onset of Immune Reconstitution Inflammatory Syndrome in TB/HIV Co-infected Patients in Rio de Janeiro, Brazil-ANRS 12274.

Carmem Beatriz Wagner Giacoia-Gripp, Andressa da Silva Cazote, Tatiana Pereira da Silva, Flávia Marinho Sant'Anna, Carolina Arana Stanis Schmaltz, Tania de Souza Brum, Juliana Arruda de Matos, Júlio Silva, Aline Benjamin, José Henrique Pilotto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Inflammasome-associated immune dysregulation in TB-HIV coinfection.Frontiers in cellular and infection microbiology · 2026
    Article
  3. Article
  4. Loss of circulating CD8αbioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Early innate cell interactions withFrontiers in immunology · 2023
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Carmem Beatriz Wagner Giacoia-GrippLaboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Brazil.
Andressa da Silva CazoteLaboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Brazil.
Tatiana Pereira da SilvaLaboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Brazil.
Flávia Marinho Sant'AnnaClinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas (FIOCRUZ), Rio de Janeiro, Brazil.
Carolina Arana Stanis SchmaltzClinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas (FIOCRUZ), Rio de Janeiro, Brazil.
Tania de Souza BrumHIV Clinical Research Center, Nova Iguaçu General Hospital (HGNI), Rio de Janeiro, Brazil.
Juliana Arruda de MatosClinical Research Laboratory on Health Surveillance and Immunization, National Institute of Infectious Diseases Evandro Chagas (FIOCRUZ), Rio de Janeiro, Brazil.
Júlio SilvaPlatform for Clinical Research, National Institute of Infectious Diseases Evandro Chagas (FIOCRUZ), Rio de Janeiro, Brazil.
Aline BenjaminClinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas (FIOCRUZ), Rio de Janeiro, Brazil.
José Henrique PilottoLaboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Brazil.
Valeria Cavalcanti RollaClinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas (FIOCRUZ), Rio de Janeiro, Brazil.
Mariza Gonçalves MorgadoLaboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Brazil.
Daniel Scott-AlgaraUnit of Lymphocyte Cell Biology, Pasteur Institute, Paris, France.
Fundação Oswaldo Cruz · BRInstitut Pasteur · FRUniversidade Iguaçu · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is the most common comorbidity and the leading cause of death among HIV-infected individuals. Although the combined antiretroviral therapy (cART) during TB treatment improves the survival of TB/HIV patients, the occurrence of immune reconstitution inflammatory syndrome (IRIS) in some patients poses clinical and scientific challenges. This work aimed to evaluate blood innate lymphocytes during therapeutic intervention for both diseases and their implications for the onset of IRIS. Natural killer (NK) cells, invariant NKT cells (iNKT), γδ T cell subsets, and

Indexed as

AdultAnti-HIV AgentsAntitubercular AgentsBrazilCoinfectionFemaleFlow CytometryFollow-Up StudiesHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeImmunity, InnateKiller Cells, NaturalMaleMiddle AgedT-Lymphocyte SubsetsAnti-HIV AgentsAntitubercular Agentsclinical outcomesinnate immune cellsIRISNK cell repertoireTB/HIV Co-infection

Identifiers

PMID31456797
PMCPMC6700218
OpenAlexW2958112692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.