ArticleFrontiers in physiology2019
Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Flecainide- and isoproterenol-induced alterations in heart rate variability and DFA-derived physiological complexity in anesthetized mice.BMC cardiovascular disorders · 2026Article
- Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation.Scientific reports · 2025Article
- Calmodulin Mutations in Human Disease.Channels (Austin, Tex.) · 2023Review
- Insights on the mechanism of flecainide in catecholaminergic polymorphic ventricular tachycardia.Journal of medicine and life · 2023Article
- Review
- How does flecainide impact RyR2 channel function?The Journal of general physiology · 2022Article
- The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.Physiological reports · 2021Article
- Role of microRNA-129 in cancer and non-cancerous diseases (Review).Experimental and therapeutic medicine · 2021Review
- Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives.Journal of clinical medicine · 2021Review
- MicroRNA-129-1-3p protects cardiomyocytes from pirarubicin-induced apoptosis by down-regulating the GRIN2D-mediated CaJournal of cellular and molecular medicine · 2020Article
- Calcium Handling Defects and Cardiac Arrhythmia Syndromes.Frontiers in pharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe dual Na
objectiveTo address this controversy, we compared FLEC in Casq2
methodsAfter 30 min exposure to FLEC (6 μM) or vehicle (VEH), spontaneous Ca
resultsIn cardiomyocytes, FLEC efficacy was dependent on extracellular [Ca
conclusionFLEC inhibits Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.