Evidence map›Paper›PMID 31456581›Full record

ArticleJMIR formative research2019

Use of Smartphone-Based Video Directly Observed Therapy (vDOT) in Tuberculosis Care: Single-Arm, Prospective Feasibility Study.

Samuel B Holzman, Sachin Atre, Tushar Sahasrabudhe, Sunil Ambike, Deepak Jagtap, Yakub Sayyad, Arjun Lal Kakrani, Amita Gupta, Vidya Mave, Maunank Shah

Abstract read
In one paragraph

Article in JMIR formative research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. eHealth in TB clinical management.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Innovative Approaches to Enhance and Measure Medication Adherence in Chronic Disease Management: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel B Holzman *Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.ORCID http://orcid.org/0000-0003-4565-8175
Sachin Atre *Dr D Y Patil Medical College, Hospital, and Research Center, Dr D Y Patil Vidyapeeth, Pune, India.ORCID http://orcid.org/0000-0003-2148-465X
Tushar SahasrabudheDr D Y Patil Medical College, Hospital, and Research Center, Dr D Y Patil Vidyapeeth, Pune, India.ORCID http://orcid.org/0000-0002-4218-0455
Sunil AmbikeDr D Y Patil Medical College, Hospital, and Research Center, Dr D Y Patil Vidyapeeth, Pune, India.ORCID http://orcid.org/0000-0003-0333-7824
Deepak JagtapDr D Y Patil Medical College, Hospital, and Research Center, Dr D Y Patil Vidyapeeth, Pune, India.ORCID http://orcid.org/0000-0002-0144-8048
Yakub SayyadDr D Y Patil Medical College, Hospital, and Research Center, Dr D Y Patil Vidyapeeth, Pune, India.ORCID http://orcid.org/0000-0002-3457-4382
Arjun Lal KakraniDr D Y Patil Medical College, Hospital, and Research Center, Dr D Y Patil Vidyapeeth, Pune, India.ORCID http://orcid.org/0000-0002-3847-010X
Amita GuptaDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.ORCID http://orcid.org/0000-0001-7036-2718
Vidya MaveDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.ORCID http://orcid.org/0000-0001-8509-4517
Maunank ShahDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States.ORCID http://orcid.org/0000-0002-0979-2388

Funding

RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
NIAID NIH HHS T32 AI007291
6 · The paper itself

Abstract

backgroundIndia accounts for nearly one-quarter of the global tuberculosis (TB) burden. Directly observed treatment (DOT) through in-person observation is recommended in India, although implementation has been heterogeneous due largely to resource limitations. Video DOT (vDOT) is a novel, smartphone-based approach that allows for remote treatment monitoring through patient-recorded videos. Prior studies in high-income, low disease burden settings, such as the United States, have shown vDOT to be feasible, although little is known about the role it may play in resource-limited, high-burden settings.

objectiveThe goal of the research was to assess the feasibility and acceptability of vDOT for adherence monitoring within a resource-limited, high TB burden setting of India.

methodsWe conducted a prospective, single-arm, pilot implementation of vDOT in Pune, India. Outcome measures included adherence (proportion of prescribed doses observed by video) and verifiable fraction (proportion of prescribed doses observed by video or verbally confirmed with the patient following an incomplete/unverifiable video submission). vDOT acceptability among patients was assessed using a posttreatment survey.

resultsA total of 25 patients enrolled. The median number of weeks on vDOT was 13 (interquartile range [IQR] 11-16). Median adherence was 74% (IQR 62%-84%), and median verifiable fraction was 86% (IQR 74%-98%). More than 90% of patients reported recording and uploading videos without difficulty.

conclusionsWe have demonstrated that vDOT may be a feasible and acceptable approach to TB treatment monitoring in India. Our work expands the evidence base around vDOT by being one of the first efforts to evaluate vDOT within a resource-limited, high TB burden setting. To our knowledge, this is the first reported use of vDOT in India.

Indexed as

Indiamedication adherencemHealthmobile phonesmartphonetelemedicinetuberculosisVideo DOT

Identifiers

PMID31456581
PMCPMC6734854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.