Evidence map›Paper›PMID 31456099›Full record

ArticleJournal of gastroenterology2020

The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.

Kathrin Hedegger, Franziska Stumpf, Helmut Blum, Alexander Graf, Roland Michael Schmid, Marina Lesina, Hana Algül, Marlon Roberto Schneider, Maik Dahlhoff

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kathrin HedeggerInstitute of Molecular Animal Breeding and Biotechnology, Gene Center of the LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.
Franziska StumpfInstitute of Molecular Animal Breeding and Biotechnology, Gene Center of the LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.
Helmut BlumLaboratory for Functional Genome Analysis (LAFUGA), Gene Center of the LMU Munich, Munich, Germany.
Alexander GrafLaboratory for Functional Genome Analysis (LAFUGA), Gene Center of the LMU Munich, Munich, Germany.
Roland Michael SchmidSecond Department of Internal Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany.
Marina LesinaSecond Department of Internal Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany.
Hana AlgülSecond Department of Internal Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany.
Marlon Roberto SchneiderInstitute of Molecular Animal Breeding and Biotechnology, Gene Center of the LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.
Maik DahlhoffInstitute of Molecular Animal Breeding and Biotechnology, Gene Center of the LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany. dahlhoff@lmb.uni-muenchen.de.ORCID http://orcid.org/0000-0001-9189-7631
Ludwig-Maximilians-Universität München · DETUM Klinikum · DEBavarian State Research Center for Agriculture · DE

Funding

Else Kröner-Fresenius-Stiftung 2010_A76
6 · The paper itself

Abstract

backgroundThe EGFR ligand betacellulin (BTC) has been previously shown to protect mice against experimentally induced acute pancreatitis (AP). BTC binds both autonomous ERBB receptors EGFR and ERBB4. In this study, we evaluated the mechanism underlying the protection from AP-associated inflammation in detail.

methodsAP was induced with cerulein or L-arginine and investigated in a pancreas-specific ERBB4 knockout and in an EGFR knockdown mouse model (Egfr

resultsWhile the pancreas of BTC transgenic mice in the background of Egfr

conclusionsThese findings suggest that BTC derivates, as a drug, or the ERBB4 receptor, as a druggable target protein, could play an important role in modulating the course of AP and even prevent AP in humans.

Indexed as

AnimalsBetacellulinDisease Models, AnimalErbB ReceptorsFemaleMaleMiceMice, KnockoutMice, TransgenicPancreatitisReceptor, ErbB-4BetacellulinEGFR protein, mouseErbb4 protein, mouseErbB ReceptorsReceptor, ErbB-4BetacellulinEpidermal growth factor receptorERBB4Extracellular matrixPancreatitis

Identifiers

PMID31456099
OpenAlexW2971006997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.