ArticleNature neuroscience2019
Aversive state processing in the posterior insular cortex.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
178 citing papers in PubMed, 2 syntheses or guidelines pooled it, 309 citations in OpenAlex.
- Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies.BMC gastroenterology · 2024Pooled it
- "Wanting" versus "needing" related value: An fMRI meta-analysis.Brain and behavior · 2022Pooled it
- Domain-General Neural Effects of Associative Learning and Expectations on Pain and Hedonic Taste Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Trial
- Amygdala and Insula Connectivity Changes Following Psychotherapy for Posttraumatic Stress Disorder: A Randomized Clinical Trial.Biological psychiatry · 2021Trial
- Resting-state functional connectivity and alexithymia: Preliminary predictive evidence.Journal of affective disorders · 2026Article
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations.Nature neuroscience · 2026Article
- Lasting aversive consequences of a single dose of 4-hydroxytamoxifen.bioRxiv : the preprint server for biology · 2026Article
- Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Whole-Brain Monosynaptic Inputs to and Axonal Projections From Posterior Insular Cortex GABAergic Neurons in Mice.CNS neuroscience & therapeutics · 2026Article
- Dual regulatory mechanisms of the ZI-LHb circuit in SPS&S model mice: dissociable control of aversion and anxiety through distinct downstream targets.Molecular psychiatry · 2026Article
- Dissociable control of depression and visceral pain by the pICNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction.Molecular psychiatry · 2026Article
- Signaling of salience and prediction errors by anterior insula neurons.Biochemical and biophysical research communications · 2026Article
- Article
- Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.Nature communications · 2026Article
- Optogenetic Hedonic Hotspots in the Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness "Liking".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
118 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral adaptation is poorly understood. By combining data from fiber photometry, optogenetics, awake two-photon calcium imaging and comprehensive whole-brain viral tracings, we here uncover a role for the posterior insula in processing aversive sensory stimuli and emotional and bodily states, as well as in exerting prominent top-down modulation of ongoing behaviors in mice. By employing projection-specific optogenetics, we describe an insula-to-central amygdala pathway to mediate anxiety-related behaviors, while an independent nucleus accumbens-projecting pathway regulates feeding upon changes in bodily state. Together, our data support a model in which the posterior insular cortex can shift behavioral strategies upon the detection of aversive internal states, providing a new entry point to understand how alterations in insula circuitry may contribute to neuropsychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.