ArticleMolecular psychiatry2020
Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Social support and telomere length: a meta-analysis.Journal of behavioral medicine · 2023Pooled it
- Bidirectional week-to-week relationships between weekly psychological stress across multiple life domains and engagement with an exercise intervention: secondary analysis of data from a randomized trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Trial
- Psychosocial risk and protective factors for men's lower urinary tract symptoms: A secondary analysis of CARDIA cohort study data.Journal of health psychology · 2026Article
- Molecular Mechanisms of Accelerated Ageing in Geriatric Depression: Interplay of Telomere Attrition, Mitochondrial Dysfunction and Cellular Senescence.International journal of molecular sciences · 2026Review
- Social determinants of health, accelerated biological aging, and long-term health outcomes.Nature communications · 2025Article
- Echoes of Inequity: A Critical Examination of the Past, Present, and Future of Cardiac Health Equity.Current cardiology reports · 2025Review
- Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.Journal of hematology & oncology · 2025Review
- The emergence of chronic diseases of adulthood and middle age in the young: the COIDS (chronic inflammation, obesity, insulin resistance/type 2 diabetes, and depressive syndromes) noxious quartet of pro-inflammatory stress outcomes.Molecular psychiatry · 2025Review
- Pathways from Adverse Childhood Family Environment to Lower Urinary Tract Symptoms and Impact Among Women.Journal of women's health (2002) · 2025Article
- Chronic Stress and Cardiovascular Events: Findings From the CARDIA Study.American journal of preventive medicine · 2024Article
- Psychological resources and incident hypertension in the coronary artery risk development in young adults (CARDIA) study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Combined effects of cumulative stress and daily stressors on daily health.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Neural correlates of stress and leucocyte telomere length in patients with coronary artery disease.Journal of psychosomatic research · 2022Article
- Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences.International journal of environmental research and public health · 2022Review
- Optimism and telomere length among African American adults in the Jackson Heart Study.Psychoneuroendocrinology · 2021Article
- Association of Early-Life Adversity With Measures of Accelerated Biological Aging Among Children in China.JAMA network open · 2020Article
- Article
- Advances in depression research: second special issue, 2020, with highlights on biological mechanisms, clinical features, co-morbidity, genetics, imaging, and treatment.Molecular psychiatry · 2020Article
- Advances in research on stress and behavior: special issue, 2020.Molecular psychiatry · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors. Past research has determined that stress experienced in adulthood is associated with shorter telomere length, but is limited to mostly cross-sectional reports. We test whether repeated reports of chronic psychosocial and financial burden is associated with telomere length change over a 5-year period (years 15 and 20) from 969 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a longitudinal, population-based cohort, ages 18-30 at time of recruitment in 1985. We further examine whether multisystem resiliency, comprised of social connections, health-maintaining behaviors, and psychological resources, mitigates the effects of repeated burden on telomere attrition over 5 years. Our results indicate that adults with high chronic burden do not show decreased telomere length over the 5-year period. However, these effects do vary by level of resiliency, as regression results revealed a significant interaction between chronic burden and multisystem resiliency. For individuals with high repeated chronic burden and low multisystem resiliency (1 SD below the mean), there was a significant 5-year shortening in telomere length, whereas no significant relationships between chronic burden and attrition were evident for those at moderate and higher levels of resiliency. These effects apply similarly across the three components of resiliency. Results imply that interventions should focus on establishing strong social connections, psychological resources, and health-maintaining behaviors when attempting to ameliorate stress-related decline in telomere length among at-risk individuals.
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